Linked Life Data

3792620

Source:http://linkedlifedata.com/resource/pubmed/id/3792620

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
1987-1-27
pubmed:abstractText
Chick sensory neurons grow to their correct targets in the hindlimb from the outset during normal development and following various experimental manipulations. This may result not because sensory neurons respond to specific limb-derived cues, but because they interact in some way with motoneurons which are responsive to such cues. To test this possibility, we removed the ventral part of the neural tube, which contains motoneurons and their precursors, at stages 16 1/2-20 1/2 and later examined the pathways sensory neurons had taken within the limb. Muscle nerves generally were missing or were reduced in diameter beyond the extent expected simply from the absence of motoneuron axons. In many cases, cutaneous nerves were enlarged, presumably due to the addition of other sensory axons. This result suggests that, in the absence of motoneurons, sensory neurons that normally project to muscles are unable to do so and may instead project along cutaneous pathways. Sensory axons from different segments also crossed less extensively in the plexus region than they did in control embryos, suggesting that alterations in their trajectories may normally be facilitated by similar changes in motoneuron pathways. Thus, motoneurons greatly enhance sensory neuron growth to muscles and contribute significantly toward the achievement of the normal sensory projection pattern. Sensory axons may fasciculate with motoneuron axons, or motoneuron axons may provide an aligned substrate for sensory neurons to grow along. Alternatively, motoneuron axons may alter the environment, thereby making certain pathways in the limb permissive for sensory neuron growth.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:month
Dec
pubmed:issn
0012-1606
pubmed:author
pubmed:issnType
Print
pubmed:volume
118
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
511-31
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed:year
1986
pubmed:articleTitle
Altered sensory projections in the chick hind limb following the early removal of motoneurons.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S.