Linked Life Data

3792406

Source:http://linkedlifedata.com/resource/pubmed/id/3792406

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
1987-2-3
pubmed:abstractText
Saccadic eye movements were examined by infrared reflection oculography in 22 patients with suspected myasthenia gravis. In all of them the diagnosis was confirmed either by electromyography, by the presence of acetylcholine-receptor antibodies (15 cases), by a positive clinical Tensilon test (4 cases), or by the course of the disease (3 cases). The aim of the study was to find out which of the saccade disorders described in myasthenic patients can be found in the early stage of the disease, and to discover their diagnostic value. Typically, saccade abnormalities were also seen in clinically uninvolved eyes. Intrasaccadic disorders mainly consisted of "decrescendo" of the velocity profiles (two-thirds of the cases) and "hypometria" (half of the cases). Postsaccadic "waver" was present in about two-thirds of the patients. The most frequent finding was "intersaccadic variation" (i.e., variation between repeated corresponding saccades) which occurred in 18 of the 22 patients, and particularly affected the velocity profiles. A standardized fatigue test proved to be useful in accentuating mild, or provoking latent pathology in most of the patients. A standardized combined examination of saccades with Tensilon yielded pathological results less frequently than hitherto described in the literature. In 4 of the 9 patients with purely ocular myasthenia gravis oculography led to the diagnosis. The problems in attempting to delimit the observed saccade abnormalities from those found in other eye movement disorders are discussed.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:issn
0175-758X
pubmed:author
pubmed:issnType
Print
pubmed:volume
236
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
102-8
pubmed:dateRevised
2004-11-17
pubmed:meshHeading
pubmed:year
1986
pubmed:articleTitle
The contribution of oculography to early diagnosis of myasthenia gravis. A study of saccadic eye movements using the infrared reflection method in 22 cases.
pubmed:publicationType
Journal Article, Case Reports