Linked Life Data

3792333

Source:http://linkedlifedata.com/resource/pubmed/id/3792333

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
1987-1-30
pubmed:abstractText
Compactin is a competitive inhibitor of the enzyme that catalyses the synthesis of mevalonate. In this study we have investigated the effects of compactin on DNA replication and cell cycle progression in animal cell cultures. We have examined several different cell types for cell cycle inhibitory effects of compactin, and although we can demonstrate that compactin inhibits mevalonate synthesis in BHK cells, we have observed little or no effect on the cell cycle. Similar results were obtained using different synchronization procedures and by measuring cell cycle progression by [3H]dThd labelling of DNA and with flow cytometry. We conclude that compactin has no appreciable and general effect on DNA replication in animal cells. These results are discussed in terms of the implications for mevalonate being a universal regulator of cell cycle progression in cultured animal cells.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jun
pubmed:issn
0171-9335
pubmed:author
pubmed:issnType
Print
pubmed:volume
41
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
121-6
pubmed:dateRevised
2005-11-17
pubmed:meshHeading
pubmed:year
1986
pubmed:articleTitle
Inhibition of mevalonate synthesis with compactin does not prevent DNA replication in cultured animal cells.
pubmed:publicationType
Journal Article