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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
51-52
|
| pubmed:dateCreated |
1987-2-17
|
| pubmed:abstractText |
From 923 breast cancers sent in for hormone receptor determination, 745 diagnostically utilizable Pappenheim-stained biopsy smears at 500-fold magnification were classified into eight atypia groups (1-4 without nucleoli, 5-8 with nucleoli) visually in terms of the severity of the cellular malignancy criteria. The hormone receptor status was determined with the dextran-coated charcoal method. Values from 10 fmol/mg estrogen receptor (ER) and (or) progesterone receptor (PR) content were designated as receptor-positive. There was a decrease in the proportion of receptor-positive results with increasing degree of atypia from 97% in group 2 (cases with only small nuclei without nucleoli) to 37% in group 7 (cases with multiple prominent nucleoli). When the average atypia values of subgroups were compared, the highest values were found for the 222 receptor-negative carcinomas. The marginally receptor-positive values were on average between the receptor-negative and the receptor-positive cases with high values. Both the low-ER and the low-PR have more pronounced criteria of malignancy compared to the respective high-receptor reference group.
|
| pubmed:language |
ger
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Dec
|
| pubmed:issn |
0012-0472
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:day |
19
|
| pubmed:volume |
111
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
1949-53
|
| pubmed:dateRevised |
2006-11-15
|
| pubmed:meshHeading | |
| pubmed:year |
1986
|
| pubmed:articleTitle |
[Cytomorphological grading and hormone receptor status in breast carcinoma. Visual studies of smear preparations].
|
| pubmed:publicationType |
Journal Article,
English Abstract,
Research Support, Non-U.S. Gov't
|