Linked Life Data

3790159

Source:http://linkedlifedata.com/resource/pubmed/id/3790159

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
24
pubmed:dateCreated
1987-1-14
pubmed:abstractText
When 14C-labeled N-(alpha-methylbenzyl)azelaamic acid (C9), which is an intermediate in the metabolism of N-(alpha-methylbenzyl)linoleamide, a potent hypocholesterolemic agent, was administered to rats, 84% of the radioactivity was recovered in the urine in 24 hr, which contained 66.1% of N-(alpha-methylbenzyl)glutaramic acid (C5) and 8.6% of N-(alpha-methylbenzyl)pimelamic acid (C7) as major metabolites. While 14C-labeled C9 was incubated with isolated hepatocytes, similar metabolites were found, whereas none of the metabolites with an even number of carbon atoms in the acyl side chain was detected. The activity of the chain-shortening of C9 by hepatocytes isolated from clofibrate-treated rats was stimulated to about twice that of untreated hepatocytes, in parallel with the elevation of C9-dependent H2O2-generation. A subcellular fractionation study of the liver revealed that the subcellular distribution of cyanide-insensitive C9-oxidation activity was coincident with that of catalase and of cyanide-insensitive palmitoyl-CoA oxidation. In this reaction, C7 and C5 were produced. For this reaction, the formation of C9-CoA thioester was essential as an intermediary step. These results indicate that peroxisomes are capable of shortening the acyl side-chains of drugs by beta-oxidation and, thus, suggest an additional metabolic role for peroxisomes.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Dec
pubmed:issn
0006-2952
pubmed:author
pubmed:issnType
Print
pubmed:day
15
pubmed:volume
35
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
4363-8
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1986
pubmed:articleTitle
Chain-shortening of a xenobiotic acyl compound by the peroxisomal beta-oxidation system in rat liver.
pubmed:publicationType
Journal Article