Linked Life Data

3786945

Source:http://linkedlifedata.com/resource/pubmed/id/3786945

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
1987-1-21
pubmed:abstractText
In an in vitro system, ketoconazole inhibited the aromatization of [4-14C]-testosterone to estradiol-17 beta by rat ovarian tissue, in a dose-related manner. The amount of an intermediate, 4-androsten-17 beta, 19-diol-3-one, formed was also reduced. When the latter steroid or a subsequent intermediate, 4-androsten-19-aldehyde-3, 17-dione, was used as substrate, ketoconazole at approximately three times the molar concentration of the substrate, depressed estradiol-17 beta synthesis to 38% and 66% of control respectively. With ketoconazole in a concentration of about thirty times that of the substrate, estradiol-17 beta synthesis was depressed to approximately 10% that of control. It is concluded that ketoconazole inhibits all three sequential hydroxylation steps leading to the ovarian aromatization of androgens.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Nov
pubmed:issn
0034-5164
pubmed:author
pubmed:issnType
Print
pubmed:volume
54
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
181-9
pubmed:dateRevised
2004-11-17
pubmed:meshHeading
pubmed:year
1986
pubmed:articleTitle
Inhibition of ovarian aromatase by ketoconazole.
pubmed:publicationType
Journal Article