Switch to
Predicate | Object |
---|---|
rdf:type | |
lifeskim:mentions | |
pubmed:issue |
1
|
pubmed:dateCreated |
1979-9-27
|
pubmed:abstractText |
Eighty-four previously untreated patients with metastatic adenocarcinoma of the large intestine received intravenous ftorafur at a dosage of 2.25 g/m2/day for 5 consecutive days. Courses were repeated every three weeks. Regressions were noted in 9 of 84 treated patients (11%). Median survival for all patients was 32 weeks. Responders survived only 5 weeks longer than nonresponders; 36 vs. 31 weeks. Central nervous system toxicity was a limiting factor occurring in one-third of patients. Ftorafur in a daily X5 schedule appears not to make a significant contribution to the management of disseminated colorectal cancer.
|
pubmed:language |
eng
|
pubmed:journal | |
pubmed:citationSubset |
AIM
|
pubmed:chemical | |
pubmed:status |
MEDLINE
|
pubmed:month |
Jul
|
pubmed:issn |
0008-543X
|
pubmed:author | |
pubmed:issnType |
Print
|
pubmed:volume |
44
|
pubmed:owner |
NLM
|
pubmed:authorsComplete |
Y
|
pubmed:pagination |
48-51
|
pubmed:dateRevised |
2006-11-15
|
pubmed:meshHeading |
pubmed-meshheading:378365-Adenocarcinoma,
pubmed-meshheading:378365-Adult,
pubmed-meshheading:378365-Aged,
pubmed-meshheading:378365-Central Nervous System,
pubmed-meshheading:378365-Colonic Neoplasms,
pubmed-meshheading:378365-Drug Evaluation,
pubmed-meshheading:378365-Female,
pubmed-meshheading:378365-Fluorouracil,
pubmed-meshheading:378365-Humans,
pubmed-meshheading:378365-Male,
pubmed-meshheading:378365-Middle Aged,
pubmed-meshheading:378365-Neoplasm Metastasis,
pubmed-meshheading:378365-Rectal Neoplasms,
pubmed-meshheading:378365-Remission, Spontaneous,
pubmed-meshheading:378365-Tegafur,
pubmed-meshheading:378365-Time Factors
|
pubmed:year |
1979
|
pubmed:articleTitle |
Phase II evaluation of ftorafur in previously untreated colorectal cancer: a Southwest Oncology Group Study.
|
pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.
|