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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
10
|
| pubmed:dateCreated |
1987-1-15
|
| pubmed:abstractText |
A new subspecies of Kibdelosporangium aridum subsp. largum (SK&F AAD-609), was isolated and shown to produce novel glycopeptides related to aridicins, but containing a homologous series of glycolipids based on N-acylglucosamine. These compounds showed improvements over the aridicins in in vitro activity and were effective in mouse protection studies against a range of Gram-positive bacteria, including methicillin resistant staphylococci. Pharmacokinetic studies indicated that they have high serum concentrations and long-acting potential. The kibdelin complex modified rumen metabolism in a manner favorable for growth promotion.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Oct
|
| pubmed:issn |
0021-8820
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
39
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
1386-94
|
| pubmed:dateRevised |
2005-11-17
|
| pubmed:meshHeading |
pubmed-meshheading:3781909-Actinomycetales,
pubmed-meshheading:3781909-Animals,
pubmed-meshheading:3781909-Anti-Bacterial Agents,
pubmed-meshheading:3781909-Cattle,
pubmed-meshheading:3781909-Culture Media,
pubmed-meshheading:3781909-Glycopeptides,
pubmed-meshheading:3781909-Intestines,
pubmed-meshheading:3781909-Male,
pubmed-meshheading:3781909-Mice,
pubmed-meshheading:3781909-Microbial Sensitivity Tests,
pubmed-meshheading:3781909-Rumen,
pubmed-meshheading:3781909-Swine
|
| pubmed:year |
1986
|
| pubmed:articleTitle |
Kibdelins, novel glycopeptide antibiotics. I. Discovery, production, and biological evaluation.
|
| pubmed:publicationType |
Journal Article
|