Switch to
Predicate | Object |
---|---|
rdf:type | |
lifeskim:mentions | |
pubmed:issue |
3
|
pubmed:dateCreated |
1987-1-2
|
pubmed:abstractText |
Potassium picloram was administered either by gavage (acute studies) or in drinking water to male and female Sprague-Dawley-derived rats (14-day and 90-day studies). The acute oral LD50 was 950 mg/kg (812-1120) for males and 686 mg/kg (599-786) for females. Depression, prostration, ataxia, tremors, and convulsions preceded death. There were no consistent biologically significant compound-related effects in rats that received 60, 190, 600 mg potassium picloram/kg/day for 14 days. In the subchronic study, rats received 60, 190, 600, or 1070 mg potassium picloram/kg/day in drinking water for 90 consecutive days. There were only 4 male and 2 female survivors out of 20 rats of each sex at the 1070 mg/kg dose and 16 male and 18 female survivors at the 600 mg/kg dose. Mortality was dose dependent. Administration of picloram appeared to exacerbate renal and hepatic lesions commonly noted in rats of this age. For example, at levels up to 1070 mg/kg mild lesions in the kidney of treated rats, especially in males at 600 mg/kg, were noted. Also noted were an increased incidence of mononuclear liver foci in male rats that received 190 and 600 mg/kg and an increased severity of mononuclear liver foci in females that received 600 mg/kg. There were no other consistent biologically significant compound-related effects. No specific organ site toxicity could be identified in these studies. Toxicity from exposure to picloram in drinking water is apparently low.
|
pubmed:language |
eng
|
pubmed:journal | |
pubmed:citationSubset |
IM
|
pubmed:chemical | |
pubmed:status |
MEDLINE
|
pubmed:month |
Oct
|
pubmed:issn |
0272-0590
|
pubmed:author | |
pubmed:issnType |
Print
|
pubmed:volume |
7
|
pubmed:owner |
NLM
|
pubmed:authorsComplete |
Y
|
pubmed:pagination |
464-70
|
pubmed:dateRevised |
2006-11-15
|
pubmed:meshHeading |
pubmed-meshheading:3781136-Animals,
pubmed-meshheading:3781136-Body Weight,
pubmed-meshheading:3781136-Drinking,
pubmed-meshheading:3781136-Female,
pubmed-meshheading:3781136-Lethal Dose 50,
pubmed-meshheading:3781136-Male,
pubmed-meshheading:3781136-Picloram,
pubmed-meshheading:3781136-Picolinic Acids,
pubmed-meshheading:3781136-Rats
|
pubmed:year |
1986
|
pubmed:articleTitle |
Acute, 14-day repeated dosing, and 90-day subchronic toxicity studies of potassium picloram.
|
pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, Non-P.H.S.
|