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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
3
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pubmed:dateCreated |
1987-1-13
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pubmed:abstractText |
Nonadherent, low density cells of dendritic morphology from the blood of patients with Hashimoto's thyroiditis were treated with human thyroglobulin (Tg) in vitro and cultured under serum-free conditions with autologous patient B cells and irradiated T cells. The patients were selected for high serum levels of IgG antithyroglobulin antibody (anti-Tg IgG). In 2 out of 12 patients the Tg-treatment induced production of anti-Tg IgG in excess of that secreted spontaneously. The amount of antibody produced in vitro (whether increased by Tg or not) correlated with the serum levels of antibody. In 5 patients (including the 2 who responded to Tg) the ratio of supernatant IgG anti-Tg antibody to total IgG was reduced when polyclonal stimulation was done with BCGF (10%). Antibody production was absent in cultures of cells from 2 patients with Graves disease and 4 normal individuals. Thus, in some patients with Hashimoto's thyroiditis, an extrinsically added autoantigen (Tg) on blood-derived dendritic cells can induce IgG anti-Tg antibody in vitro. These data suggest that "professional" antigen-presenting cells may play a role in autoimmune thyroid disease.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
|
pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
Dec
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pubmed:issn |
0090-1229
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
41
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
433-42
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:3780057-Aged,
pubmed-meshheading:3780057-Antigen-Presenting Cells,
pubmed-meshheading:3780057-Autoantibodies,
pubmed-meshheading:3780057-Dendritic Cells,
pubmed-meshheading:3780057-Dose-Response Relationship, Immunologic,
pubmed-meshheading:3780057-Female,
pubmed-meshheading:3780057-Humans,
pubmed-meshheading:3780057-Immunoglobulin G,
pubmed-meshheading:3780057-Male,
pubmed-meshheading:3780057-Middle Aged,
pubmed-meshheading:3780057-Thyroglobulin,
pubmed-meshheading:3780057-Thyroiditis, Autoimmune
|
pubmed:year |
1986
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pubmed:articleTitle |
Thyroglobulin-treated blood dendritic cells induce IgG anti-thyroglobulin antibody in vitro in Hashimoto's thyroiditis.
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pubmed:publicationType |
Journal Article,
In Vitro
|