Linked Life Data

3779391

Source:http://linkedlifedata.com/resource/pubmed/id/3779391

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
1987-1-6
pubmed:abstractText
Single unit recording of rat inferior olivary nucleus neurons reveals significantly elevated discharge after acute intraperitoneal injection of 2 g/kg ethanol. This effect is consistent across 3 different methods of anesthesia and immobilization: local Xylocaine plus intraperitoneal D-tubocurare, intraperitoneal chloral hydrate and halothane vapor. In contrast, under urethane anesthesia acute ethanol produces significant depression of olivary discharge. Since this effect is opposite to that found under the other anesthetic conditions (including topical Xylocaine only), urethane anesthesia may compromise generalizations of electrophysiologic studies of ethanol. Neurons of the inferior olivary nucleus excite cerebellar Purkinje cells through a powerful afferent circuit; our data therefore suggest that ethanol-induced increases in cerebellar Purkinje cell complex (climbing fiber burst) spikes, obtained in our previous studies, are secondary to olivary activation.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Oct
pubmed:issn
0006-8993
pubmed:author
pubmed:issnType
Print
pubmed:day
22
pubmed:volume
385
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
253-62
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed:year
1986
pubmed:articleTitle
Ethanol increases single unit activity in the inferior olivary nucleus.
pubmed:publicationType
Journal Article, Comparative Study, Research Support, U.S. Gov't, P.H.S.