Linked Life Data

3777152

Source:http://linkedlifedata.com/resource/pubmed/id/3777152

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
5 Pt 1
pubmed:dateCreated
1986-12-12
pubmed:abstractText
We describe a method by which the ionic surround of an isolated frog heart cell can be changed within a small fraction of a contraction cycle while continuously measuring contraction force. With this method, we have investigated the effect on force development of changing the extracellular concentrations of Ca [( Ca]o) and Na [( Na]o) in the period between electrically driven contractions and during the rising phase of a contraction. Raising or lowering either [Ca]o or [Na]o more than 300 ms prior to a stimulus caused peak force of the next contraction to be changed 100% of the way to the steady-state value characteristic of the new ionic concentrations. Similar maneuvers at later times relative to the stimulus caused progressively smaller changes. Lowering [Ca]o from 2 to 1 mM or raising [Na]o from 78 to 110 mM 100 ms after stimulation brought twitch force 35 and 67% of the way to the new steady states, respectively. We conclude that extracellular Ca is the source of activator Ca in these cells and that extracellular Na plays a role in regulation of the intracellular Ca concentration early in the contraction cycle.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Nov
pubmed:issn
0002-9513
pubmed:author
pubmed:issnType
Print
pubmed:volume
251
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
C653-61
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1986
pubmed:articleTitle
Direct control of contraction force of single frog atrial cells by extracellular ions.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't