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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
2
|
pubmed:dateCreated |
1986-12-18
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pubmed:abstractText |
Magnocellular neurosecretory cells (MNCs) were impaled in perfused explants of rat hypothalamus. Application of a voltage clamp after 1-5 current-evoked spikes revealed a tetrodotoxin-resistant, but Cd2+-sensitive inward current. From a threshold near -85 mV, the amplitude of this current increased as post-spike commands were made to more positive potentials. Following its activation, the current-voltage relation of the cell displayed a region of negative resistance which crossed the spike threshold. This Ca2+-dependent spike after-current can therefore induce and sustain burst firing in MNCs.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
|
pubmed:chemical | |
pubmed:status |
MEDLINE
|
pubmed:month |
Oct
|
pubmed:issn |
0304-3940
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pubmed:author | |
pubmed:issnType |
Print
|
pubmed:day |
8
|
pubmed:volume |
70
|
pubmed:owner |
NLM
|
pubmed:authorsComplete |
Y
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pubmed:pagination |
204-9
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading | |
pubmed:year |
1986
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pubmed:articleTitle |
Calcium-dependent spike after-current induces burst firing in magnocellular neurosecretory cells.
|
pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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