Linked Life Data

3770465

Source:http://linkedlifedata.com/resource/pubmed/id/3770465

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
1986-12-2
pubmed:abstractText
Mutations of the gene tra-3 result in partial masculinization of XX animals of C. elegans, which are normally hermaphrodites (males are XO). A total of 43 tra-3 revertants (one intragenic, 42 extragenic) have been isolated and analyzed, in the hope of identifying new sex-determination loci. Most (38) of the extra-genic suppressors cause partial or complete feminization of XX and XO animals; the remaining four are weak suppressors. The feminizing suppressors are mostly alleles of known sex-determining genes: tra-1 (11 dominant alleles), tra-2 (one dominant allele), fem-1 (four alleles) and fem-2 (four alleles), but 18 are alleles of a new gene, fem-3. Additional alleles have been isolated for the fem-2 and fem-3 genes, as well as fem-3 deficiencies. Mutations in fem-3 resemble alleles of fem-1 (previously characterized): putative null alleles result in complete feminization of XX and XO animals, transforming them into fertile females. Severe alleles of fem-2 also cause complete feminization of XX animals at all temperatures, but feminization of fem-2 XO animals is temperature-sensitive: complete at 25 degrees, incomplete at 20 degrees. As with fem-1, severe mutations of fem-2 and fem-3 are wholly epistatic to masculinizing alleles of tra-2 and tra-3, and epistatic to tra-1 masculinizing alleles in the germline, but not in the soma. All three fem genes are essential for male development and appear to have a dual role in promoting spermatogenesis and repressing tra-1 activity. All three fem genes exhibit strong maternal effects; the maternal contribution of fem gene products may be inactivated in XX animals by a posttranscriptional mechanism. Maternal contributions of wild-type fem-3 product are necessary for normal XO male development and XX hermaphrodite (as opposed to female) development.
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/3770465-11813735, http://linkedlifedata.com/resource/pubmed/commentcorrection/3770465-17246299, http://linkedlifedata.com/resource/pubmed/commentcorrection/3770465-17248988, http://linkedlifedata.com/resource/pubmed/commentcorrection/3770465-295035, http://linkedlifedata.com/resource/pubmed/commentcorrection/3770465-4366476, http://linkedlifedata.com/resource/pubmed/commentcorrection/3770465-6468762, http://linkedlifedata.com/resource/pubmed/commentcorrection/3770465-6627397, http://linkedlifedata.com/resource/pubmed/commentcorrection/3770465-6760802, http://linkedlifedata.com/resource/pubmed/commentcorrection/3770465-6866126, http://linkedlifedata.com/resource/pubmed/commentcorrection/3770465-700253, http://linkedlifedata.com/resource/pubmed/commentcorrection/3770465-7202837, http://linkedlifedata.com/resource/pubmed/commentcorrection/3770465-7274656, http://linkedlifedata.com/resource/pubmed/commentcorrection/3770465-7286433, http://linkedlifedata.com/resource/pubmed/commentcorrection/3770465-943344
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:month
Sep
pubmed:issn
0016-6731
pubmed:author
pubmed:issnType
Print
pubmed:volume
114
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
15-52
pubmed:dateRevised
2010-11-18
pubmed:meshHeading
pubmed:year
1986
pubmed:articleTitle
Sex determination in the nematode C. elegans: analysis of tra-3 suppressors and characterization of fem genes.
pubmed:publicationType
Journal Article