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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
12
|
| pubmed:dateCreated |
1986-12-17
|
| pubmed:abstractText |
Blood-brain barrier (BBB) permeability to 24Na+, 36Cl-, and [3H]sucrose was studied in rats after 2 wk of streptozocin-induced diabetes. The PS (permeability-surface area product) for Na+ in the cortex of the frontal lobes was 5.4 +/- 0.6 (10(-5) cm3 X g-1 X s-1; +/- SD) in diabetic rats compared with 7.1 +/- 1.7 in control rats. In the occipital cortex, the values were 7.6 +/- 1.5 and 9.9 +/- 1.6, respectively. In contrast, BBB permeability to Cl- and sucrose remained unchanged. We conclude that a selective alteration in BBB permeability to Na+ unrelated to changes in brain capillary surface area is present in experimental diabetes.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
AIM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Dec
|
| pubmed:issn |
0012-1797
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
35
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
1371-3
|
| pubmed:dateRevised |
2003-11-14
|
| pubmed:meshHeading |
pubmed-meshheading:3770313-Animals,
pubmed-meshheading:3770313-Blood-Brain Barrier,
pubmed-meshheading:3770313-Chlorides,
pubmed-meshheading:3770313-Diabetes Mellitus, Experimental,
pubmed-meshheading:3770313-Glucose,
pubmed-meshheading:3770313-Male,
pubmed-meshheading:3770313-Rats,
pubmed-meshheading:3770313-Rats, Inbred Strains,
pubmed-meshheading:3770313-Sodium,
pubmed-meshheading:3770313-Sucrose
|
| pubmed:year |
1986
|
| pubmed:articleTitle |
Decreased blood-brain barrier permeability to sodium in early experimental diabetes.
|
| pubmed:publicationType |
Journal Article
|