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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
5
|
pubmed:dateCreated |
1986-11-24
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pubmed:abstractText |
The effect of actinomycin D (0.4 mg/kg) on radiation-induced lung damage in the mouse was investigated. The drug was administered either 4 weeks before, immediately after, or 16 weeks after single doses of 240 kV X-rays applied to the thorax of CBA mice. Lung damage was assessed by measuring respiration rate, with a whole body plethysmograph. Dose-response curves were obtained at 2-week intervals from 12 to 40 weeks after irradiation. Actinomycin D had no significant effect on respiration rate in this study. A summary of other experimental studies is included which shows conflicting results.
|
pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
|
pubmed:chemical | |
pubmed:status |
MEDLINE
|
pubmed:month |
May
|
pubmed:issn |
0277-5379
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pubmed:author | |
pubmed:issnType |
Print
|
pubmed:volume |
22
|
pubmed:owner |
NLM
|
pubmed:authorsComplete |
Y
|
pubmed:pagination |
577-82
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:3770029-Animals,
pubmed-meshheading:3770029-Dactinomycin,
pubmed-meshheading:3770029-Dose-Response Relationship, Radiation,
pubmed-meshheading:3770029-Lung,
pubmed-meshheading:3770029-Male,
pubmed-meshheading:3770029-Mice,
pubmed-meshheading:3770029-Mice, Inbred CBA,
pubmed-meshheading:3770029-Radiation-Sensitizing Agents,
pubmed-meshheading:3770029-Respiration,
pubmed-meshheading:3770029-Respiratory Insufficiency
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pubmed:year |
1986
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pubmed:articleTitle |
Actinomycin D and radiation: effects on mouse lung.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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