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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
3
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pubmed:dateCreated |
1986-11-18
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pubmed:abstractText |
Chronic phencyclidine (PCP) administration has been shown to produce tolerance to a number of its pharmacological actions. We have suggested that PCP interacts with the 5-HT2 receptors since it inhibits [3H]spiperone binding to 5-HT2 receptors in vitro. In the present study, we investigated whether methysergide (a 5-HT2 receptor blocker) induces the precipitated withdrawal syndrome in PCP-tolerant rats. The body weight of the rats in the abrupt and precipitated withdrawal groups was significantly lower 5 days and 1-5 days after withdrawal, respectively, than that in the control group. Furthermore, other typical precipitated abstinence syndrome characteristics such as jumping, wet-dog shake and ptosis were also observed in the precipitated withdrawal group. These results suggest that PCP produces its behavioral effects via an agonistic interaction with 5-HT2 receptor sites and that our method may be very useful for the development of a rat model for studying physical dependence on PCP.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
|
pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
Sep
|
pubmed:issn |
0304-3940
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:day |
12
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pubmed:volume |
69
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pubmed:owner |
NLM
|
pubmed:authorsComplete |
Y
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pubmed:pagination |
275-8
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:3763058-Animals,
pubmed-meshheading:3763058-Male,
pubmed-meshheading:3763058-Methysergide,
pubmed-meshheading:3763058-Phencyclidine,
pubmed-meshheading:3763058-Rats,
pubmed-meshheading:3763058-Rats, Inbred F344,
pubmed-meshheading:3763058-Receptors, Serotonin,
pubmed-meshheading:3763058-Substance Withdrawal Syndrome,
pubmed-meshheading:3763058-Substance-Related Disorders
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pubmed:year |
1986
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pubmed:articleTitle |
Methysergide-induced precipitated withdrawal syndrome in phencyclidine-dependent rats.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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