Linked Life Data

3762562

Source:http://linkedlifedata.com/resource/pubmed/id/3762562

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
1986-10-30
pubmed:abstractText
Cisplatin binds to cellular macromolecules (DNA, RNA and protein) to the same extent in wild-type Walker rat carcinoma cells and a variant sub-line of these cells resistant to cisplatin and to other difunctional, but not monofunctional cytotoxic agents. Wild-type Walker cells exhibit a unique sensitivity to DNA-bound cisplatin, while the resistant cells have a sensitivity that approximates to that of many normal and other tumour cell lines. Total DNA-bound adducts were lost from both sensitive and resistant Walker cells at similar rates. Equal numbers of DNA interstrand crosslinks and DNA-protein crosslinks were formed in both cell lines, and the rate of loss of both types of crosslinks was similar in the two lines. Therefore the unusual sensitivity of Walker cells to cisplatin is not due to a defect in their ability to remove these platinum-DNA adducts.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Sep
pubmed:issn
0027-5107
pubmed:author
pubmed:issnType
Print
pubmed:volume
166
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
157-68
pubmed:dateRevised
2003-11-14
pubmed:meshHeading
pubmed:year
1986
pubmed:articleTitle
Walker rat carcinoma cells are exceptionally sensitive to cis-diamminedichloroplatinum(II) (cisplatin) and other difunctional agents but not defective in the removal of platinum-DNA adducts.
pubmed:publicationType
Journal Article