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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
3
|
pubmed:dateCreated |
1986-11-20
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pubmed:abstractText |
Malassezia furfur (Pityrosporum orbiculare) was confirmed by microscopic potassium hydroxide (KOH) examination in 101 patients with recurring lesions of tinea versicolor. In a double-blind comparative study, patients were randomly assigned to once-daily ketoconazole 2% or placebo cream. At the end of treatment, 98% (p less than 0.0001) of the patients using ketoconazole and 28% of those using placebo responded clinically (healed or had mild residual disease). There was an overall 84% mycologic cure rate (negative KOH at treatment end) for patients using ketoconazole 2% cream and 10% for those using placebo cream (p less than 0.0001). Ketoconazole-treated patients who were cured at the end of treatment remained cured 8 weeks later. By contrast 75% of those responding to placebo had relapsed by the 8-week follow-up visit. Follow-up after 2 years revealed that 79% (38/48) of the patients treated with ketoconazole remained clear 12 or more months.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
|
pubmed:month |
Sep
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pubmed:issn |
0190-9622
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
15
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
500-3
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pubmed:dateRevised |
2004-11-17
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pubmed:meshHeading |
pubmed-meshheading:3760275-Administration, Topical,
pubmed-meshheading:3760275-Adolescent,
pubmed-meshheading:3760275-Adult,
pubmed-meshheading:3760275-Aged,
pubmed-meshheading:3760275-Double-Blind Method,
pubmed-meshheading:3760275-Female,
pubmed-meshheading:3760275-Follow-Up Studies,
pubmed-meshheading:3760275-Humans,
pubmed-meshheading:3760275-Ketoconazole,
pubmed-meshheading:3760275-Male,
pubmed-meshheading:3760275-Middle Aged,
pubmed-meshheading:3760275-Ointments,
pubmed-meshheading:3760275-Random Allocation,
pubmed-meshheading:3760275-Tinea Versicolor
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pubmed:year |
1986
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pubmed:articleTitle |
Double-blind comparison of 2% ketoconazole cream and placebo in the treatment of tinea versicolor.
|
pubmed:publicationType |
Journal Article,
Clinical Trial,
Randomized Controlled Trial
|