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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
2
|
pubmed:dateCreated |
1986-11-12
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pubmed:abstractText |
A human minigastrin-II analog was prepared by conventional methods in solution using N-benzyloxycarbonyltyrosine O-sulfate as starting material in the synthetic route. Upon removal of the acid-labile protecting groups and purification by preparative reversed-phase chromatography the sulfated gastrin peptide was obtained in satisfactory overall yields as homogeneous material. It was found to be about twice as active as the non-sulfated form in stimulating gastric acid secretion and to exhibit a 10-fold higher affinity to gastrin receptors of purified parietal cells.
|
pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
|
pubmed:chemical | |
pubmed:status |
MEDLINE
|
pubmed:month |
Oct
|
pubmed:issn |
0014-5793
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pubmed:author | |
pubmed:issnType |
Print
|
pubmed:day |
6
|
pubmed:volume |
206
|
pubmed:owner |
NLM
|
pubmed:authorsComplete |
Y
|
pubmed:pagination |
203-7
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pubmed:dateRevised |
2008-11-21
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pubmed:meshHeading |
pubmed-meshheading:3758347-Animals,
pubmed-meshheading:3758347-Chemical Phenomena,
pubmed-meshheading:3758347-Chemistry,
pubmed-meshheading:3758347-Chromatography, High Pressure Liquid,
pubmed-meshheading:3758347-Gastric Acid,
pubmed-meshheading:3758347-Gastrins,
pubmed-meshheading:3758347-Humans,
pubmed-meshheading:3758347-Male,
pubmed-meshheading:3758347-Parietal Cells, Gastric,
pubmed-meshheading:3758347-Rabbits,
pubmed-meshheading:3758347-Rats,
pubmed-meshheading:3758347-Receptors, Cholecystokinin,
pubmed-meshheading:3758347-Sulfates
|
pubmed:year |
1986
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pubmed:articleTitle |
Synthesis of human des-tryptophan-1,norleucine-12-minigastrin-II and its biological activities.
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pubmed:publicationType |
Journal Article,
Comparative Study
|