Linked Life Data

3757431

Source:http://linkedlifedata.com/resource/pubmed/id/3757431

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
1986-11-10
pubmed:abstractText
Serum calcium was measured under different circumstances of thyroid dysfunction in male Sprague-Dawley and female Wistar rats. After induction of hypothyroidism with 131I and propylthiouracil, serum calcium fell from a control value of 2.43 +/- 0.08 mmol/l to 2.07 +/- 0.08 mmol/l (P less than 0.01). Thyroid hormone replacement therapy in hypothyroid rats caused a return of serum calcium to control values (2.09 +/- 0.04 mmol/l to 2.41 +/- 0.02 mmol/l, P less than 0.01). Treatment of normal rats with thyroid hormones caused elevation of serum calcium to 2.59 +/- 0.04 mmol/l compared with a control value of 2.44 +/- 0.02 mmol/l (P less than 0.01). Time-course studies demonstrated a slow decline in serum calcium levels over a 10 week period during induction of hypothyroidism with propylthiouracil alone but a very rapid normalization of serum calcium (within 1 h) after replacement therapy with L-tri-iodothyronine. These data illustrate the considerable influence that thyroid hormones exert on calcium metabolism and demonstrate for the first time consistent changes in serum calcium in the rat with hypo- and hyper-thyroidism.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Sep
pubmed:issn
0143-5221
pubmed:author
pubmed:issnType
Print
pubmed:volume
71
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
271-6
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1986
pubmed:articleTitle
Effects of thyroid dysfunction on serum calcium in the rat.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't