Switch to
| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
2
|
| pubmed:dateCreated |
1986-10-31
|
| pubmed:abstractText |
We have examined the murine cell-mediated immune (CMI) response to collagens type I (CI) and type II (CII) as measured by in vivo delayed-type hypersensitivity responses. We have verified the histopathology and kinetics of the cell-mediated immune responses. Predominant cell-mediated responses were obtained 7, 10, or 14 days following immunization. A presumed antibody-mediated reaction was observed at later times (e.g., greater than 21 days following immunization). The CMI responses to the collagens show a strain-dependent relationship. For CI, the CMI response profile shows H-2b greater than or equal to H-2k = H-2q much greater than H-2d. For bovine CII, the response profile is H-2d greater than H-2b = H-2k = H-2q; the chick CII response profile is H-2q = H-2k greater than H-2b = H-2d, and in limited testing, only the H-2q strain could generate murine CII-specific cell-mediated immune responses. The CII-specific CMI response is cross-reactive with CII from several species of animals, but not with CI. Further, the collagen-specific CMI response can be elicited with certain cyanogen-bromide fragments of bovine CII. Finally, our study also demonstrates that there is a non-H-2-linked locus(i) involved in the development of CII-induced arthritis.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Jul
|
| pubmed:issn |
0008-8749
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
100
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
314-30
|
| pubmed:dateRevised |
2003-11-14
|
| pubmed:meshHeading |
pubmed-meshheading:3757042-Animals,
pubmed-meshheading:3757042-Arthritis, Experimental,
pubmed-meshheading:3757042-Cattle,
pubmed-meshheading:3757042-Collagen,
pubmed-meshheading:3757042-Cross Reactions,
pubmed-meshheading:3757042-Ear, External,
pubmed-meshheading:3757042-Foot,
pubmed-meshheading:3757042-Hypersensitivity, Delayed,
pubmed-meshheading:3757042-Immunity, Cellular,
pubmed-meshheading:3757042-Immunization,
pubmed-meshheading:3757042-Inflammation,
pubmed-meshheading:3757042-Mice,
pubmed-meshheading:3757042-Mice, Inbred BALB C,
pubmed-meshheading:3757042-Mice, Inbred C57BL,
pubmed-meshheading:3757042-Mice, Inbred CBA,
pubmed-meshheading:3757042-Mice, Inbred DBA,
pubmed-meshheading:3757042-Mice, Inbred Strains,
pubmed-meshheading:3757042-Mice, Mutant Strains,
pubmed-meshheading:3757042-Rats,
pubmed-meshheading:3757042-Species Specificity
|
| pubmed:year |
1986
|
| pubmed:articleTitle |
Characteristics of cellular immune responses to collagen type I or collagen type II.
|
| pubmed:publicationType |
Journal Article
|