Linked Life Data

3756466

Source:http://linkedlifedata.com/resource/pubmed/id/3756466

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
1986-11-13
pubmed:abstractText
Spiny branchlets of cerebellar Purkinje neurons, thought to be sites of synaptic efficacy change during motor learning, degenerate during aging. To examine effects of behavioral experience on degeneration, Purkinje neurons were studied in aging rats housed for 4.5 months either under complex environment conditions promoting sensory-motor activity or in pairs in standard cages. Their data were compared with those of a baseline group of rats from standard cages sacrificed at the age of onset of differential housing for the older groups. Rats housed in the complex environment had more spiny branchlets than the other groups, indicating that new branches had formed. There was a net loss of summed total spiny branchlet material per Purkinje cell in both the laboratory cage and complex environment older groups, although the complex environment group had more spiny branchlet per cell than the laboratory cage group. Thus, dendrite loss in the aging cerebellum can be partly offset by appropriate experience. There was no net loss of Purkinje cell main branch dendrite with aging, as indicated by previous studies, and there was no effect of differential housing upon main branches in the older groups. However, changes in the pattern of branching in the main dendritic field suggested that this region undergoes reorganization with aging.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:month
Aug
pubmed:issn
0006-8993
pubmed:author
pubmed:issnType
Print
pubmed:day
13
pubmed:volume
380
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
136-43
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1986
pubmed:articleTitle
Environmental conditions modulate degeneration and new dendrite growth in cerebellum of senescent rats.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't