| pubmed-article:3756210 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:3756210 | lifeskim:mentions | umls-concept:C0034721 | lld:lifeskim |
| pubmed-article:3756210 | lifeskim:mentions | umls-concept:C0034693 | lld:lifeskim |
| pubmed-article:3756210 | lifeskim:mentions | umls-concept:C0026336 | lld:lifeskim |
| pubmed-article:3756210 | lifeskim:mentions | umls-concept:C0032105 | lld:lifeskim |
| pubmed-article:3756210 | lifeskim:mentions | umls-concept:C0025955 | lld:lifeskim |
| pubmed-article:3756210 | lifeskim:mentions | umls-concept:C0031453 | lld:lifeskim |
| pubmed-article:3756210 | lifeskim:mentions | umls-concept:C0031454 | lld:lifeskim |
| pubmed-article:3756210 | lifeskim:mentions | umls-concept:C0333668 | lld:lifeskim |
| pubmed-article:3756210 | pubmed:issue | 3 | lld:pubmed |
| pubmed-article:3756210 | pubmed:dateCreated | 1986-11-7 | lld:pubmed |
| pubmed-article:3756210 | pubmed:abstractText | Microencapsulation of the enzyme phenylalanine ammonia-lyase was developed for in vivo depletion of systemic phenylalanine in phenylketonuric rats. Compared to normal rats, systemic phenylalanine blood levels in phenylketonuric rats was increased by 15-20-fold. Daily oral administration of 1 unit of phenylalanine ammonia-lyase-loaded artificial cells to phenylketonuric rats lowered the systemic phenylalanine level to 58% +/- 18% (mean + S.D.) in 7 days (P less than 0.010), while 5 units lowered the systemic phenylalanine level to 25% +/- 8%. 5 units of the immobilized enzyme lowered the systemic phenylalanine level to normal levels within 6 days. Phenylketonuric treated rats showed no signs of abnormal behavior and weight loss compared to phenylketonuric non-treated rats. The immobilized enzyme within artificial cells is therefore protected against low gastrointestinal pH and proteolytic enzymes. | lld:pubmed |
| pubmed-article:3756210 | pubmed:language | eng | lld:pubmed |
| pubmed-article:3756210 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3756210 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:3756210 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3756210 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3756210 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3756210 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3756210 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3756210 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:3756210 | pubmed:month | Oct | lld:pubmed |
| pubmed-article:3756210 | pubmed:issn | 0006-3002 | lld:pubmed |
| pubmed-article:3756210 | pubmed:author | pubmed-author:ChangT MTM | lld:pubmed |
| pubmed-article:3756210 | pubmed:author | pubmed-author:BourgetLL | lld:pubmed |
| pubmed-article:3756210 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:3756210 | pubmed:day | 1 | lld:pubmed |
| pubmed-article:3756210 | pubmed:volume | 883 | lld:pubmed |
| pubmed-article:3756210 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:3756210 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:3756210 | pubmed:pagination | 432-8 | lld:pubmed |
| pubmed-article:3756210 | pubmed:dateRevised | 2009-11-19 | lld:pubmed |
| pubmed-article:3756210 | pubmed:meshHeading | pubmed-meshheading:3756210-... | lld:pubmed |
| pubmed-article:3756210 | pubmed:meshHeading | pubmed-meshheading:3756210-... | lld:pubmed |
| pubmed-article:3756210 | pubmed:meshHeading | pubmed-meshheading:3756210-... | lld:pubmed |
| pubmed-article:3756210 | pubmed:meshHeading | pubmed-meshheading:3756210-... | lld:pubmed |
| pubmed-article:3756210 | pubmed:meshHeading | pubmed-meshheading:3756210-... | lld:pubmed |
| pubmed-article:3756210 | pubmed:meshHeading | pubmed-meshheading:3756210-... | lld:pubmed |
| pubmed-article:3756210 | pubmed:meshHeading | pubmed-meshheading:3756210-... | lld:pubmed |
| pubmed-article:3756210 | pubmed:meshHeading | pubmed-meshheading:3756210-... | lld:pubmed |
| pubmed-article:3756210 | pubmed:meshHeading | pubmed-meshheading:3756210-... | lld:pubmed |
| pubmed-article:3756210 | pubmed:meshHeading | pubmed-meshheading:3756210-... | lld:pubmed |
| pubmed-article:3756210 | pubmed:year | 1986 | lld:pubmed |
| pubmed-article:3756210 | pubmed:articleTitle | Phenylalanine ammonia-lyase immobilized in microcapsules for the depletion of phenylalanine in plasma in phenylketonuric rat model. | lld:pubmed |
| pubmed-article:3756210 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:3756210 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:3756210 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:3756210 | lld:pubmed |
