Linked Life Data

375514

Source:http://linkedlifedata.com/resource/pubmed/id/375514

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
1979-7-25
pubmed:abstractText
An interaction of polyamines with protein kinases activities from T. cruzi epimastigotes is demonstrated. Spermine and spermidine and less pronounced putrescine are found to inhibit protein kinases activities. In the extract of T. cruzi three protein kinases are distinguished on account of molecular weight (greater than 200 000, 95 000 and 40 000) and preference for acceptor proteins (phosvitin and histones). Especially the activity of the high molecular weight protein kinase which phosphorylates phosvitin is strongly inhibited by spermine and spermidine. The type of inhibition by both polyamines is found to be non-competitive with respect to ATP as well as phosvitin. The inhibition constants for spermine and spermidine are determined to be 1.4 mM and 2.0 nM, respectively.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Mar
pubmed:issn
0303-4208
pubmed:author
pubmed:issnType
Print
pubmed:volume
30
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
9-12
pubmed:dateRevised
2009-11-19
pubmed:meshHeading
pubmed:year
1979
pubmed:articleTitle
Effect of polyamines on protein kinases activities from Trypanosoma cruzi.
pubmed:publicationType
Journal Article