Linked Life Data

3753697

Source:http://linkedlifedata.com/resource/pubmed/id/3753697

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
1986-3-20
pubmed:abstractText
The level of the in vitro chemotactic responsiveness of murine inflammatory peritoneal macrophages is dependent upon the genetic background of the host. A survey of the responses of macrophages from various inbred strains showed three categories of response (high, intermediate, and low), indicating that genetic control is multigenic. Among the high responder strains were those derived from the C57BL (B) background, while mice of the A/J (A) strain exhibited the lowest response. In order to determine the number of genes controlling the level of macrophage chemotactic responses, segregation analysis of backcross mice derived from high responder B and low responder A parental mice was performed. The results of analysis of the data by the maximum likelihood modeling, a computerized method, showed that the difference in macrophage chemotactic responsiveness in the strain combination of B and A mice is due to the effects of two autosomal genetic loci.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0093-7711
pubmed:author
pubmed:issnType
Print
pubmed:volume
23
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
11-7
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1986
pubmed:articleTitle
Macrophage chemotactic response in mice is controlled by two genetic loci.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't