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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
5
|
| pubmed:dateCreated |
1986-10-22
|
| pubmed:abstractText |
Irradiation of skin with ultraviolet B (UVB) stimulates epidermal activity of ornithine decarboxylase (ODC), a rate limiting polyamine biosynthesing enzyme. The maximum stimulation of ODC activity by UVB was found at 24 after irradiation. Systemic administration of a polyprenoic acid derivative (E-5166) significantly inhibited the UVB-stimulated ODC activity in a dose-dependent manner. The inhibitory effect of E-5166 on the UVB-stimulated ODC activity was found to begin at 5 mg/kg body weight. These results indicate that because it inhibits ODC activity E-5166 can be utilized for the treatment of hyperproliferative skin diseases.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:issn |
0340-3696
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
278
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
407-9
|
| pubmed:dateRevised |
2003-11-14
|
| pubmed:meshHeading |
pubmed-meshheading:3753036-Animals,
pubmed-meshheading:3753036-Etretinate,
pubmed-meshheading:3753036-Kinetics,
pubmed-meshheading:3753036-Male,
pubmed-meshheading:3753036-Mice,
pubmed-meshheading:3753036-Ornithine Decarboxylase,
pubmed-meshheading:3753036-Skin,
pubmed-meshheading:3753036-Tretinoin,
pubmed-meshheading:3753036-Ultraviolet Rays
|
| pubmed:year |
1986
|
| pubmed:articleTitle |
A novel synthetic vitamin-A-like compound (a polyprenoic acid derivative: E-5166) inhibits UVB-stimulated epidermal ornithine decarboxylase activity.
|
| pubmed:publicationType |
Journal Article
|