Linked Life Data

3753023

Source:http://linkedlifedata.com/resource/pubmed/id/3753023

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
9
pubmed:dateCreated
1986-10-16
pubmed:abstractText
Experimental models of meningeal gliomatosis (MG) have been produced by intracisternal inoculation of human glioma cell lines into nude mice. The tumor growth was steady and fast in MG nude mice if 10(7) cells were implanted. Median survival time (MST) of nude mice inoculated with tumor cells was inversely related to the number of cells inoculated. There was a correlation between in vitro and in vivo (MG models) growth rate, which means that the cell kinetics in vitro are reflected in vivo. The clinicopathological features observed in nude mouse MG models were similar to those seen in diffuse leptomeningeal involvement of gliomas in humans. The models will be useful for investigating the pathophysiology of meningeal gliomatosis and the efficacy of chemotherapeutic agents.
pubmed:language
jpn
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:month
Sep
pubmed:issn
0385-0684
pubmed:author
pubmed:issnType
Print
pubmed:volume
13
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
2745-50
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1986
pubmed:articleTitle
[Development of experimental meningeal gliomatosis models using nude mice].
pubmed:publicationType
Journal Article, English Abstract