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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
3
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pubmed:dateCreated |
1979-7-25
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pubmed:abstractText |
Salmonella typhimurium strain TM677 was mutagenized with aflatoxin B1 (AFB1) in liquid suspension culture in the presence of a rat liver postmitochondrial supernatant. Forward mutation to 8-azaguanine resistance was measured in the treated cultures and was found to increase linearly with AFB1 concentration. DNA purified from mutagenized cells was analyzed for AFB1 adduct formation by high-pressure liquid chromatography after adduct liberation. AFB1 exposures at 0.16 and 0.32 micrometer for 35 min produced 15 and 22 AFB1--DNA adducts per genome, respectively, and induced 8-azaguanine-resistant fractions of 4.9 X 10(-4) and 9.6 X 10(-4). Approximately 70% of the AFB1 bound to DNA was chromatographically identical to 2,3-dihydro-2-(N7-guanyl)-3-hydroxyaflatoxin B1 at the two AFB1 levels used.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/375236-1090579,
http://linkedlifedata.com/resource/pubmed/commentcorrection/375236-1139740,
http://linkedlifedata.com/resource/pubmed/commentcorrection/375236-13278318,
http://linkedlifedata.com/resource/pubmed/commentcorrection/375236-13363951,
http://linkedlifedata.com/resource/pubmed/commentcorrection/375236-14367363,
http://linkedlifedata.com/resource/pubmed/commentcorrection/375236-14907713,
http://linkedlifedata.com/resource/pubmed/commentcorrection/375236-165497,
http://linkedlifedata.com/resource/pubmed/commentcorrection/375236-187331,
http://linkedlifedata.com/resource/pubmed/commentcorrection/375236-201606,
http://linkedlifedata.com/resource/pubmed/commentcorrection/375236-266709,
http://linkedlifedata.com/resource/pubmed/commentcorrection/375236-273905,
http://linkedlifedata.com/resource/pubmed/commentcorrection/375236-343109,
http://linkedlifedata.com/resource/pubmed/commentcorrection/375236-360221,
http://linkedlifedata.com/resource/pubmed/commentcorrection/375236-4378427,
http://linkedlifedata.com/resource/pubmed/commentcorrection/375236-4429559,
http://linkedlifedata.com/resource/pubmed/commentcorrection/375236-4564486,
http://linkedlifedata.com/resource/pubmed/commentcorrection/375236-4866372,
http://linkedlifedata.com/resource/pubmed/commentcorrection/375236-5335942,
http://linkedlifedata.com/resource/pubmed/commentcorrection/375236-768755,
http://linkedlifedata.com/resource/pubmed/commentcorrection/375236-895848,
http://linkedlifedata.com/resource/pubmed/commentcorrection/375236-922734
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Mar
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pubmed:issn |
0027-8424
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
76
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1343-7
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
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pubmed:year |
1979
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pubmed:articleTitle |
Aflatoxin B1 mutagenesis, DNA binding, and adduct formation in Salmonella typhimurium.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.
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