Linked Life Data

3749366

Source:http://linkedlifedata.com/resource/pubmed/id/3749366

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
1986-9-26
pubmed:abstractText
Ethylenethiourea (ETU) is a degradation product from ethylenebisdithiocarbamate such as Zineb and Maneb which have been extensively used in food crops and ornamental plants. Khera (1973, 1975, 1977) reported that administration of ETU to pregnant rats could induce anomalies in the visceral organs and the central nervous system of fetuses in food toxicology. From this point, in an attempt to better understand the pathomechanism of teratogenesis in the central nervous system, we have studied the effects of ETU on the central nervous system of rat fetuses. In this study, pregnant Sprague Dawley (SD) rats were used and subjected to ETU. Various types of congenital malformations of the central nervous system are presented in rat fetuses including spinal dysraphism associated with hindbrain crowding, exencephaly, meningoencephalocele, microencephaly, hydraencephaly and hydrocephalus. Each depended on the gestation days of the ETU administration and dosages.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Apr
pubmed:issn
0255-6596
pubmed:author
pubmed:issnType
Print
pubmed:volume
10
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
127-36
pubmed:dateRevised
2008-2-26
pubmed:meshHeading
pubmed:year
1986
pubmed:articleTitle
Experimental production of congenital malformation of the central nervous system in rat fetuses by single dose intragastric administration of ethylenethiourea.
pubmed:publicationType
Journal Article