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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
3
|
pubmed:dateCreated |
1979-7-16
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pubmed:abstractText |
All of our Escherichia coli C mutants blocked in the first step of D-arabitol catabolism (D-arabitol dehydrogenase) became unable to grow in the presence of D-arabitol. We have shown that this sensitivity is eliminated by a defect in the second enzyme of the pathway (D-xylulokinase), leading to a pattern of toxicity and its relief which has not been previously reported. We have found a similar pattern of toxicity and its relief in the closely related ribitol pathway. The evolutionary significance of these findings is discussed.
|
pubmed:language |
eng
|
pubmed:journal | |
pubmed:citationSubset |
IM
|
pubmed:chemical | |
pubmed:status |
MEDLINE
|
pubmed:month |
Mar
|
pubmed:issn |
0022-2844
|
pubmed:author | |
pubmed:issnType |
Print
|
pubmed:day |
15
|
pubmed:volume |
12
|
pubmed:owner |
NLM
|
pubmed:authorsComplete |
Y
|
pubmed:pagination |
189-95
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pubmed:dateRevised |
2010-11-18
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pubmed:meshHeading |
pubmed-meshheading:374747-Alcohol Oxidoreductases,
pubmed-meshheading:374747-Arabinose,
pubmed-meshheading:374747-Biological Evolution,
pubmed-meshheading:374747-Drug Resistance, Microbial,
pubmed-meshheading:374747-Escherichia coli,
pubmed-meshheading:374747-Genes,
pubmed-meshheading:374747-Genotype,
pubmed-meshheading:374747-Mutation,
pubmed-meshheading:374747-Species Specificity,
pubmed-meshheading:374747-Sugar Alcohols
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pubmed:year |
1979
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pubmed:articleTitle |
A unique pattern of toxic synthesis in pentitol catabolism: implications for evolution.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, U.S. Gov't, Non-P.H.S.
|