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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
4
|
pubmed:dateCreated |
1986-10-6
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pubmed:abstractText |
The effect of immunomodulatory lectins on diabetes development following low-dose streptozotocin treatment in inbred mice was studied. All lectins administered had been shown previously to suppress immune reactivity. Among plant lectins concanavalin A but not Lens culinaris or wheat germ agglutinin partially suppressed hyperglycaemia following low-dose streptozotocin. A similar inhibitory effect was found for the staphylococcal enterotoxin B. Finally, administration of an immunomodulatory lectin from vertebrates, electrolectin, also had a beneficial effect on the course of the disease. These findings indicate that some lectins have a suppressive effect on Type 1 diabetes in an animal model.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
|
pubmed:month |
May
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pubmed:issn |
0265-5985
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pubmed:author | |
pubmed:issnType |
Print
|
pubmed:volume |
3
|
pubmed:owner |
NLM
|
pubmed:authorsComplete |
Y
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pubmed:pagination |
183-6
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pubmed:dateRevised |
2007-9-11
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pubmed:meshHeading |
pubmed-meshheading:3742941-Animals,
pubmed-meshheading:3742941-Blood Glucose,
pubmed-meshheading:3742941-Body Weight,
pubmed-meshheading:3742941-Diabetes Mellitus, Experimental,
pubmed-meshheading:3742941-Immunosuppression,
pubmed-meshheading:3742941-Lectins,
pubmed-meshheading:3742941-Male,
pubmed-meshheading:3742941-Mice,
pubmed-meshheading:3742941-Mice, Inbred C57BL
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pubmed:year |
1986
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pubmed:articleTitle |
Suppression of low-dose streptozotocin-induced diabetes by immunomodulatory lectins.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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