| pubmed-article:3742730 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:3742730 | lifeskim:mentions | umls-concept:C0024121 | lld:lifeskim |
| pubmed-article:3742730 | lifeskim:mentions | umls-concept:C0242706 | lld:lifeskim |
| pubmed-article:3742730 | lifeskim:mentions | umls-concept:C0598934 | lld:lifeskim |
| pubmed-article:3742730 | lifeskim:mentions | umls-concept:C0392747 | lld:lifeskim |
| pubmed-article:3742730 | lifeskim:mentions | umls-concept:C1554963 | lld:lifeskim |
| pubmed-article:3742730 | pubmed:issue | 9 | lld:pubmed |
| pubmed-article:3742730 | pubmed:dateCreated | 1986-10-17 | lld:pubmed |
| pubmed-article:3742730 | pubmed:abstractText | The effects of hyperoxia on lung tumor development were examined in mice and rats. In mice, exposure to 70% O2 prevented the development of urethan- or 3-methylcholanthrene-induced lung tumors. Dietary antioxidants [butylated hydroxytoluene (BHT) and butylated hydroxyanisole (BHA)] were unable to prevent the inhibition of tumor development by oxygen, although BHT retained its capability to enhance tumor development in mouse lung. In visible-size tumors, oxygen did not depress DNA synthesis. Oxygen also reduced the number of pulmonary metastatic nodules after i.v. injection of mammary gland-derived carcinoma cells, but failed to inhibit growth of murine lung carcinoma or murine melanoma-derived cell lines. Rats treated with one single intratracheal instillation of 3-methylcholanthrene developed multiple lung lesions; their growth could be prevented by exposure of the animals to 40 or 70% O2. It is concluded that hyperoxia prevents development of transformed cells in vivo in the lung and may affect adversely the growth of selected cell lines metastatic to the lung. | lld:pubmed |
| pubmed-article:3742730 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3742730 | pubmed:language | eng | lld:pubmed |
| pubmed-article:3742730 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3742730 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:3742730 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:3742730 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3742730 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:3742730 | pubmed:month | Sep | lld:pubmed |
| pubmed-article:3742730 | pubmed:issn | 0143-3334 | lld:pubmed |
| pubmed-article:3742730 | pubmed:author | pubmed-author:GriesemerR... | lld:pubmed |
| pubmed-article:3742730 | pubmed:author | pubmed-author:WitschiH PHP | lld:pubmed |
| pubmed-article:3742730 | pubmed:author | pubmed-author:Lindenschmidt... | lld:pubmed |
| pubmed-article:3742730 | pubmed:author | pubmed-author:MargarettenNN | lld:pubmed |
| pubmed-article:3742730 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:3742730 | pubmed:volume | 7 | lld:pubmed |
| pubmed-article:3742730 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:3742730 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:3742730 | pubmed:pagination | 1581-6 | lld:pubmed |
| pubmed-article:3742730 | pubmed:dateRevised | 2007-11-14 | lld:pubmed |
| pubmed-article:3742730 | pubmed:meshHeading | pubmed-meshheading:3742730-... | lld:pubmed |
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| pubmed-article:3742730 | pubmed:meshHeading | pubmed-meshheading:3742730-... | lld:pubmed |
| pubmed-article:3742730 | pubmed:year | 1986 | lld:pubmed |
| pubmed-article:3742730 | pubmed:articleTitle | Modification of lung tumor growth by hyperoxia. | lld:pubmed |
| pubmed-article:3742730 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:3742730 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:3742730 | pubmed:publicationType | Research Support, U.S. Gov't, Non-P.H.S. | lld:pubmed |
| pubmed-article:3742730 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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