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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
3
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pubmed:dateCreated |
1979-7-16
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pubmed:abstractText |
delta9-Tetrahydrocannabinol (delta9-THC) inhibits pituitary gonadotropin secretion in castrated rhesus monkeys. Also, delta9-THC blocks the ovulatory reflux in rabbits. We report now the dose-response relationship of precoital single doses of delta9-THC on luteinizing hormone (LH) release and ovulation in the rabbit. Forty-five female rabbits in estrous were divided into nine groups of five animals. Groups 1 to 5 received a single intramuscular dose of delta9-THC (5,2.5, 1.25, 0.612, and 0.306 mg/kg, respectively) 2 hours before mating; animals of group 6 received vehicle only. In animals of groups 7 and 8 ovulation was induced with 100 IU of human chorionic gonadotropic (hCG), given intravenously 2 hours after the administration of delta9-THC (5 mg/kg) or vehicle. Rabbit luteinizing hormone (rLH) was measured in plasma 90 to 120 minutes after coitus or hCG administration. After the injection of 5 mg of delta9-THC, luteinizing hormone-releasing factor (LH-RF) (20 microgram intravenously) was administered to the animals of group 9. All animals of groups 6, 7, and 8 ovulated. A dose-response curve was observed in the animals treated with delta9-THC and natural mating. Whereas none of the animals treated with 5 or 2.5 mg/kg ovulated, one of the group treated with 1.25 mg/kg, two of the group treated with 0.612 mg/kg, and all treated with 0.312 mg/kg ovulated. Ovulations correlated with postcoital levels of rLH. All animals of group 9 ovulated, indicating that the site of action of delta9-THC is suprapituitary, probably hypothalamic.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Chorionic Gonadotropin,
http://linkedlifedata.com/resource/pubmed/chemical/Gonadotropin-Releasing Hormone,
http://linkedlifedata.com/resource/pubmed/chemical/Luteinizing Hormone,
http://linkedlifedata.com/resource/pubmed/chemical/Tetrahydrocannabinol
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pubmed:status |
MEDLINE
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pubmed:month |
Mar
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pubmed:issn |
0015-0282
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
31
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
331-4
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:374129-Animals,
pubmed-meshheading:374129-Chorionic Gonadotropin,
pubmed-meshheading:374129-Copulation,
pubmed-meshheading:374129-Dose-Response Relationship, Drug,
pubmed-meshheading:374129-Female,
pubmed-meshheading:374129-Gonadotropin-Releasing Hormone,
pubmed-meshheading:374129-Hypothalamus,
pubmed-meshheading:374129-Injections, Intramuscular,
pubmed-meshheading:374129-Luteinizing Hormone,
pubmed-meshheading:374129-Ovulation,
pubmed-meshheading:374129-Rabbits,
pubmed-meshheading:374129-Tetrahydrocannabinol
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pubmed:year |
1979
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pubmed:articleTitle |
Precoital single doses of delta9-tetrahydrocannabinol block ovulation in the rabbit.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.
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