Linked Life Data

3741266

Source:http://linkedlifedata.com/resource/pubmed/id/3741266

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:dateCreated
1986-9-16
pubmed:abstractText
A lactose-specific lectin present in the haemolymph of the colonial ascidian Botrylloides leachii was tested for its ability to act as an opsonin for the phagocytosis of erythrocytes by mouse macrophages. Sensitization of sheep or mouse erythrocytes with one agglutinating dose of the invertebrate agglutinin enhanced significantly the clearance of these cells from the circulation of mice, as did treatment with specific antibody. By measuring the adhesion and phagocytosis of 51Cr-labelled erythrocytes by monolayers of macrophages in vitro, it was shown that the B. leachii agglutinin was highly opsonic, promoting the ingestion of erythrocytes by the macrophages with an initial efficiency similar to that of specific antibody. The adherence and ingestion of antibody-coated erythrocytes was severely inhibited by blocking Fc receptors on the macrophages with soluble immune complexes, whereas the binding and ingestion of lectin-coated erythrocytes was unaffected by this treatment. The results demonstrate that invertebrate lectins can act as efficient opsonins for the uptake of particles by vertebrate phagocytes and that it is not necessary for particles to bind to Fc receptors for phagocytosis to be induced.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Apr
pubmed:issn
0004-945X
pubmed:author
pubmed:issnType
Print
pubmed:volume
64 ( Pt 2)
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
105-18
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1986
pubmed:articleTitle
Fc receptor-independent phagocytosis by mouse macrophages of erythrocytes sensitized with a lectin from a marine invertebrate.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't