Linked Life Data

3739622

Source:http://linkedlifedata.com/resource/pubmed/id/3739622

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
1986-9-16
pubmed:abstractText
Diabetic encephalopathy is a relatively frequent late complication in human and experimental diabetes mellitus. Although it is generally assumed that microangiopathy plays a major role in its pathogenesis, many aspects of the latter are still poorly understood. To detect possible correlations between vascular and cellular changes, we examined in normotensive and spontaneously hypertensive streptozotocin diabetic rats the neurons of hypothalamic and cortical regions in which the capillary basement membrane thickness had been known from a previous study. Arcuate and ventromedial nucleus neurons of normotensive diabetic rats compared to those of corresponding controls showed a reduced cytoplasmic area after 4 but not after 8 months of experiment. No difference was found between hypertensive control and diabetic rats after either 4 or 8 months of experiment. After the 8th month cortical neurons of normotensive controls were smaller in an occipital than in a frontal region and within the same region in the following layer order: deep less than superficial less than intermediate. Neurons of hypertensive controls behaved comparably yet were generally smaller than those of normotensive controls in each corresponding region. Compared to those of control, cortical neurons of normotensive diabetic rats were smaller in superficial and deep layers of both regions and in the intermediate layer of the frontal region. Hypertension appeared to antagonize diabetes. Despite an arcuate nucleus microangiopathy found in rats from both strains after 4 and 8 months of diabetes, neuronal changes were seen only in normotensive animals after 4 months. In the intermediate cortical layer, where microangiopathy was most marked after 8 months of experiment, neurons were not or only slightly reduced in size.(ABSTRACT TRUNCATED AT 250 WORDS)
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:issn
0001-6322
pubmed:author
pubmed:issnType
Print
pubmed:volume
70
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
135-41
pubmed:dateRevised
2007-11-9
pubmed:meshHeading
pubmed:year
1986
pubmed:articleTitle
Hypothalamic and cortical neurons of normotensive and spontaneously hypertensive rats are differently affected by streptozotocin diabetes.
pubmed:publicationType
Journal Article, Comparative Study, Research Support, Non-U.S. Gov't