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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
4
|
| pubmed:dateCreated |
1986-9-17
|
| pubmed:abstractText |
Serum concentration of dantrolene and its active metabolite, 5-hydroxydantrolene were determined in 27 cerebral palsy patients. Correlation coefficients between the oral dose of dantrolene and serum levels of dantrolene and its major metabolite, 5-hydroxydantrolene were rather small in cerebral palsy patients. The mean half-times of dantrolene and 5-hydroxydantrolene were 3.41 (n = 6) and 4.00 (n = 5) hours, respectively. These values were about a half of those reported earlier [Lietman et al., 1974; Meyler et al., 1979; Flewellen et al., 1983]. The poor correlation between serum level and dose may be due to the variation in an extent of oral dantrolene availability.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:issn |
0270-322X
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
5
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
253-9
|
| pubmed:dateRevised |
2004-11-17
|
| pubmed:meshHeading |
pubmed-meshheading:3737270-Adolescent,
pubmed-meshheading:3737270-Adult,
pubmed-meshheading:3737270-Cerebral Palsy,
pubmed-meshheading:3737270-Child,
pubmed-meshheading:3737270-Child, Preschool,
pubmed-meshheading:3737270-Dantrolene,
pubmed-meshheading:3737270-Dose-Response Relationship, Drug,
pubmed-meshheading:3737270-Female,
pubmed-meshheading:3737270-Humans,
pubmed-meshheading:3737270-Kinetics,
pubmed-meshheading:3737270-Male,
pubmed-meshheading:3737270-Metabolic Clearance Rate
|
| pubmed:year |
1986
|
| pubmed:articleTitle |
Relationship between serum concentration and daily dose of dantrolene in cerebral palsy patients.
|
| pubmed:publicationType |
Journal Article
|