Linked Life Data

3736753

Source:http://linkedlifedata.com/resource/pubmed/id/3736753

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
1986-9-25
pubmed:abstractText
The effects of the neurotoxicant, trimethyltin (TMT), on the acquisition of serial position response chains (learning) in adult rats were examined. Animals performing incremental repeated acquisition tasks for food were injected once with either 7.5 or 8.7 mg/kg TMT, IP. TMT decreased efficiencies (correct/total responses) in all 5 subjects; maximal decrements occurred 1-3 weeks post-treatment. Efficiency in 3 rats returned to pre-TMT levels within 5 weeks; values for the other 2 animals did not return in 3 months. Errors were markedly increased 1-2 weeks post-treatment in 4/5 subjects. Response rates increased for 2 animals within a week of TMT treatment and remained elevated for 5 weeks. Sustained rate increases occurred for 2 other animals 4-5 weeks after treatment. Thus, TMT effects on various aspects of incremental repeated acquisition behavior follow different time-courses.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0275-1380
pubmed:author
pubmed:issnType
Print
pubmed:volume
8
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
245-53
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:articleTitle
Effects of trimethyltin on incremental repeated acquisition (learning) in the rat.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, Non-P.H.S.