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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
8
|
| pubmed:dateCreated |
1986-9-17
|
| pubmed:abstractText |
Diastereoisomers of 3,17 beta-dihydroxy-20,21-epoxy-19-norpregna-1,3,5(10)-triene have been prepared as potential antitumor agents. Both isomers undergo the base-catalyzed Payne rearrangement. The isomers were cytotoxic to mammalian cells in culture and were able to displace [3H]estradiol from binding sites in rat uterine cytosols with 1/7 and 1/70 the potency of estradiol. The reasons for this difference are discussed.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Aug
|
| pubmed:issn |
0022-2623
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
29
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
1537-40
|
| pubmed:dateRevised |
2006-11-15
|
| pubmed:meshHeading |
pubmed-meshheading:3735321-Animals,
pubmed-meshheading:3735321-Antineoplastic Agents,
pubmed-meshheading:3735321-Cell Survival,
pubmed-meshheading:3735321-Estradiol,
pubmed-meshheading:3735321-Female,
pubmed-meshheading:3735321-Norpregnatrienes,
pubmed-meshheading:3735321-Rats,
pubmed-meshheading:3735321-Receptors, Estrogen,
pubmed-meshheading:3735321-Stereoisomerism,
pubmed-meshheading:3735321-Structure-Activity Relationship,
pubmed-meshheading:3735321-Uterus
|
| pubmed:year |
1986
|
| pubmed:articleTitle |
3,17 beta-Dihydroxy-20,21-epoxy-19-norpregna-1,3,5(10)-trienes: synthesis, rearrangement, cytotoxicity, and estrogen-receptor binding.
|
| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|