| pubmed-article:37351 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:37351 | lifeskim:mentions | umls-concept:C0000768 | lld:lifeskim |
| pubmed-article:37351 | lifeskim:mentions | umls-concept:C1708480 | lld:lifeskim |
| pubmed-article:37351 | lifeskim:mentions | umls-concept:C2756969 | lld:lifeskim |
| pubmed-article:37351 | lifeskim:mentions | umls-concept:C0010417 | lld:lifeskim |
| pubmed-article:37351 | lifeskim:mentions | umls-concept:C0266425 | lld:lifeskim |
| pubmed-article:37351 | lifeskim:mentions | umls-concept:C0012203 | lld:lifeskim |
| pubmed-article:37351 | lifeskim:mentions | umls-concept:C0332157 | lld:lifeskim |
| pubmed-article:37351 | lifeskim:mentions | umls-concept:C0004083 | lld:lifeskim |
| pubmed-article:37351 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:37351 | pubmed:dateCreated | 1979-9-25 | lld:pubmed |
| pubmed-article:37351 | pubmed:abstractText | Epididymal cysts and/or hypoplastic testes have been found in 31.5 per cent of 308 men exposed to diethylstilbestrol in utero, compared to 7.8 per cent of 307 placebo-exposed controls. Analyses of the spermatozoa have revealed severe pathological changes (Eliasson score greater than 10) in 134 diethylstilbestrol-exposed men (18 per cent) and 87 placebo-exposed men (8 per cent). Further investigation of the 26 diethylstilbestrol-exposed men with testicular hypoplasia has revealed that 65 per cent had a history of cryptorchidism. Only 1 of the 6 placebo-exposed controls with testicular hypoplasia had a history of testicular maldescent. Although none of our Diekmann's lying-in study group has had carcinoma to date one must keep in mind the reported increased risk of testicular carcinoma in testes that are or were cryptorchid. A 25-year-old man who was not part of the study group was treated recently by us for a testicular carcinoma ( mixed anaplastic seminoma plus embryonal cell carcinoma) and he had a history of diethylstilbestrol exposure in utero and cryptorchidism. | lld:pubmed |
| pubmed-article:37351 | pubmed:keyword | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:37351 | pubmed:keyword | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:37351 | pubmed:keyword | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:37351 | pubmed:keyword | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:37351 | pubmed:keyword | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:37351 | pubmed:keyword | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:37351 | pubmed:keyword | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:37351 | pubmed:keyword | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:37351 | pubmed:keyword | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:37351 | pubmed:keyword | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:37351 | pubmed:keyword | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:37351 | pubmed:keyword | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:37351 | pubmed:keyword | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:37351 | pubmed:keyword | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:37351 | pubmed:keyword | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:37351 | pubmed:keyword | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:37351 | pubmed:keyword | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:37351 | pubmed:keyword | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:37351 | pubmed:keyword | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:37351 | pubmed:keyword | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:37351 | pubmed:keyword | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:37351 | pubmed:language | eng | lld:pubmed |
| pubmed-article:37351 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:37351 | pubmed:citationSubset | AIM | lld:pubmed |
| pubmed-article:37351 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:37351 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:37351 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:37351 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:37351 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:37351 | pubmed:month | Jul | lld:pubmed |
| pubmed-article:37351 | pubmed:issn | 0022-5347 | lld:pubmed |
| pubmed-article:37351 | pubmed:author | pubmed-author:SchumacherG... | lld:pubmed |
| pubmed-article:37351 | pubmed:author | pubmed-author:SchoenbergH... | lld:pubmed |
| pubmed-article:37351 | pubmed:author | pubmed-author:StrausF... | lld:pubmed |
| pubmed-article:37351 | pubmed:author | pubmed-author:BibboMM | lld:pubmed |
| pubmed-article:37351 | pubmed:author | pubmed-author:GillW BWB | lld:pubmed |
| pubmed-article:37351 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:37351 | pubmed:volume | 122 | lld:pubmed |
| pubmed-article:37351 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:37351 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:37351 | pubmed:pagination | 36-9 | lld:pubmed |
| pubmed-article:37351 | pubmed:dateRevised | 2007-11-15 | lld:pubmed |
| pubmed-article:37351 | pubmed:otherAbstract | PIP: 31.5% of 308 men exposed to diethylstilbestrol (DES) in utero had epididymal cysts and/or hypoplastic testes compared with 7.8% of 307 placebo-exposed controls. Analyses of the sperm revealed severe pathological changes (Eliasson score 10) in 134 DES-exposed men (18%) and 87 placebo-exposed men (8%). 26 DES-exposed men with testicular hypoplasia were further investigated, and 65% had a history of cryptorchidism. Only 1/6 placebo-exposed controls with testicular hypoplasia had a history of testicular maldescent. Although none of the 300 men exposed to DES in this 2-decade-old double-blind prospective study has had carcinoma to date, the reported increased risk of testicular carcinoma in testes that are or were cryptorchid must be remembered. A 25-year-old man who was not part of the prospective study group was treated recently by the authors for a testicular carcinoma (a mixed anaplastic seminoma plus embryonal cell carcinoma) and he had a history of DES exposure in utero and cryptorchidism. | lld:pubmed |
| pubmed-article:37351 | pubmed:meshHeading | pubmed-meshheading:37351-Ep... | lld:pubmed |
| pubmed-article:37351 | pubmed:meshHeading | pubmed-meshheading:37351-Se... | lld:pubmed |
| pubmed-article:37351 | pubmed:meshHeading | pubmed-meshheading:37351-Sp... | lld:pubmed |
| pubmed-article:37351 | pubmed:meshHeading | pubmed-meshheading:37351-Te... | lld:pubmed |
| pubmed-article:37351 | pubmed:meshHeading | pubmed-meshheading:37351-Hu... | lld:pubmed |
| pubmed-article:37351 | pubmed:meshHeading | pubmed-meshheading:37351-Pr... | lld:pubmed |
| pubmed-article:37351 | pubmed:meshHeading | pubmed-meshheading:37351-Fo... | lld:pubmed |
| pubmed-article:37351 | pubmed:meshHeading | pubmed-meshheading:37351-Di... | lld:pubmed |
| pubmed-article:37351 | pubmed:meshHeading | pubmed-meshheading:37351-Te... | lld:pubmed |
| pubmed-article:37351 | pubmed:meshHeading | pubmed-meshheading:37351-Pr... | lld:pubmed |
| pubmed-article:37351 | pubmed:meshHeading | pubmed-meshheading:37351-Cr... | lld:pubmed |
| pubmed-article:37351 | pubmed:meshHeading | pubmed-meshheading:37351-Pl... | lld:pubmed |
| pubmed-article:37351 | pubmed:meshHeading | pubmed-meshheading:37351-Fe... | lld:pubmed |
| pubmed-article:37351 | pubmed:meshHeading | pubmed-meshheading:37351-Ma... | lld:pubmed |
| pubmed-article:37351 | pubmed:meshHeading | pubmed-meshheading:37351-Cy... | lld:pubmed |
| pubmed-article:37351 | pubmed:meshHeading | pubmed-meshheading:37351-Ad... | lld:pubmed |
| pubmed-article:37351 | pubmed:meshHeading | pubmed-meshheading:37351-Ma... | lld:pubmed |
| pubmed-article:37351 | pubmed:meshHeading | pubmed-meshheading:37351-Cl... | lld:pubmed |
| pubmed-article:37351 | pubmed:meshHeading | pubmed-meshheading:37351-Ab... | lld:pubmed |
| pubmed-article:37351 | pubmed:meshHeading | pubmed-meshheading:37351-Lu... | lld:pubmed |
| pubmed-article:37351 | pubmed:year | 1979 | lld:pubmed |
| pubmed-article:37351 | pubmed:articleTitle | Association of diethylstilbestrol exposure in utero with cryptorchidism, testicular hypoplasia and semen abnormalities. | lld:pubmed |
| pubmed-article:37351 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:37351 | pubmed:publicationType | Clinical Trial | lld:pubmed |
| pubmed-article:37351 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:37351 | pubmed:publicationType | Controlled Clinical Trial | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:37351 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:37351 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:37351 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:37351 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:37351 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:37351 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:37351 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:37351 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:37351 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:37351 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:37351 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:37351 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:37351 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:37351 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:37351 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:37351 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:37351 | lld:pubmed |
