Switch to
| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
1
|
| pubmed:dateCreated |
1979-9-25
|
| pubmed:abstractText |
Epididymal cysts and/or hypoplastic testes have been found in 31.5 per cent of 308 men exposed to diethylstilbestrol in utero, compared to 7.8 per cent of 307 placebo-exposed controls. Analyses of the spermatozoa have revealed severe pathological changes (Eliasson score greater than 10) in 134 diethylstilbestrol-exposed men (18 per cent) and 87 placebo-exposed men (8 per cent). Further investigation of the 26 diethylstilbestrol-exposed men with testicular hypoplasia has revealed that 65 per cent had a history of cryptorchidism. Only 1 of the 6 placebo-exposed controls with testicular hypoplasia had a history of testicular maldescent. Although none of our Diekmann's lying-in study group has had carcinoma to date one must keep in mind the reported increased risk of testicular carcinoma in testes that are or were cryptorchid. A 25-year-old man who was not part of the study group was treated recently by us for a testicular carcinoma ( mixed anaplastic seminoma plus embryonal cell carcinoma) and he had a history of diethylstilbestrol exposure in utero and cryptorchidism.
|
| pubmed:keyword |
http://linkedlifedata.com/resource/pubmed/keyword/Biology,
http://linkedlifedata.com/resource/pubmed/keyword/Contraceptive Agents, Estrogen,
http://linkedlifedata.com/resource/pubmed/keyword/Diethylstilbestrol--side effects,
http://linkedlifedata.com/resource/pubmed/keyword/Double-blind Studies,
http://linkedlifedata.com/resource/pubmed/keyword/Endocrine System,
http://linkedlifedata.com/resource/pubmed/keyword/Estrogens,
http://linkedlifedata.com/resource/pubmed/keyword/Genital Effects, Male,
http://linkedlifedata.com/resource/pubmed/keyword/Genitalia,
http://linkedlifedata.com/resource/pubmed/keyword/Genitalia, Male,
http://linkedlifedata.com/resource/pubmed/keyword/Hormones,
http://linkedlifedata.com/resource/pubmed/keyword/Maternal-fetal Exchange,
http://linkedlifedata.com/resource/pubmed/keyword/Men,
http://linkedlifedata.com/resource/pubmed/keyword/Physiology,
http://linkedlifedata.com/resource/pubmed/keyword/Pregnancy,
http://linkedlifedata.com/resource/pubmed/keyword/Reproduction,
http://linkedlifedata.com/resource/pubmed/keyword/Research Methodology,
http://linkedlifedata.com/resource/pubmed/keyword/Semen--analysis,
http://linkedlifedata.com/resource/pubmed/keyword/Seminal Vesicles,
http://linkedlifedata.com/resource/pubmed/keyword/Studies,
http://linkedlifedata.com/resource/pubmed/keyword/Testis,
http://linkedlifedata.com/resource/pubmed/keyword/Urogenital System
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
AIM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Jul
|
| pubmed:issn |
0022-5347
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
122
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
36-9
|
| pubmed:dateRevised |
2007-11-15
|
| pubmed:otherAbstract |
PIP: 31.5% of 308 men exposed to diethylstilbestrol (DES) in utero had epididymal cysts and/or hypoplastic testes compared with 7.8% of 307 placebo-exposed controls. Analyses of the sperm revealed severe pathological changes (Eliasson score 10) in 134 DES-exposed men (18%) and 87 placebo-exposed men (8%). 26 DES-exposed men with testicular hypoplasia were further investigated, and 65% had a history of cryptorchidism. Only 1/6 placebo-exposed controls with testicular hypoplasia had a history of testicular maldescent. Although none of the 300 men exposed to DES in this 2-decade-old double-blind prospective study has had carcinoma to date, the reported increased risk of testicular carcinoma in testes that are or were cryptorchid must be remembered. A 25-year-old man who was not part of the prospective study group was treated recently by the authors for a testicular carcinoma (a mixed anaplastic seminoma plus embryonal cell carcinoma) and he had a history of DES exposure in utero and cryptorchidism.
|
| pubmed:meshHeading |
pubmed-meshheading:37351-Abnormalities, Drug-Induced,
pubmed-meshheading:37351-Adult,
pubmed-meshheading:37351-Clinical Trials as Topic,
pubmed-meshheading:37351-Cryptorchidism,
pubmed-meshheading:37351-Cysts,
pubmed-meshheading:37351-Diethylstilbestrol,
pubmed-meshheading:37351-Epididymis,
pubmed-meshheading:37351-Female,
pubmed-meshheading:37351-Follicle Stimulating Hormone,
pubmed-meshheading:37351-Humans,
pubmed-meshheading:37351-Luteinizing Hormone,
pubmed-meshheading:37351-Male,
pubmed-meshheading:37351-Maternal-Fetal Exchange,
pubmed-meshheading:37351-Placebos,
pubmed-meshheading:37351-Pregnancy,
pubmed-meshheading:37351-Prospective Studies,
pubmed-meshheading:37351-Semen,
pubmed-meshheading:37351-Spermatozoa,
pubmed-meshheading:37351-Testicular Neoplasms,
pubmed-meshheading:37351-Testis
|
| pubmed:year |
1979
|
| pubmed:articleTitle |
Association of diethylstilbestrol exposure in utero with cryptorchidism, testicular hypoplasia and semen abnormalities.
|
| pubmed:publicationType |
Journal Article,
Clinical Trial,
Research Support, U.S. Gov't, P.H.S.,
Controlled Clinical Trial
|