Linked Life Data

3733365

Source:http://linkedlifedata.com/resource/pubmed/id/3733365

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
1986-9-17
pubmed:abstractText
Highly metastatic cell lines have been isolated from lung foci formed by the intravenous injection of large numbers (5 X 10(6)) of cells of a poorly metastatic rat mammary adenocarcinoma (DMBA-8). The metastatic variant lines were phenotypically different and, unlike the parent line, produced high levels of plasminogen activator (PA) separable into three major bands (MW 30,000, 48,000 and 83,000) on SDS-PAGE. It is suggested that PA may play a role in the enhanced metastatic ability of these cells. Using parallel DMBA-8 clones the rate of generation of the metastatic variant cells was estimated, by fluctuation analysis, to be approximately 1.85 X 10(-6) per cell generation.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0251-1789
pubmed:author
pubmed:issnType
Print
pubmed:volume
6
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
133-44
pubmed:dateRevised
2003-11-14
pubmed:meshHeading
pubmed:year
1986
pubmed:articleTitle
Enhanced plasminogen activator production by highly metastatic variant cell lines of a rat mammary adenocarcinoma.
pubmed:publicationType
Journal Article