Switch to
Predicate | Object |
---|---|
rdf:type | |
lifeskim:mentions | |
pubmed:issue |
1
|
pubmed:dateCreated |
1986-9-16
|
pubmed:abstractText |
Rats were gavaged with 60, 48, 38, 30, or 24 ml/kg of either petroleum (P) or shale (S)-derived distillate fuel, marine (DFM). Surviving rats were killed 14 days after dosing. There was a slight difference in toxicity of the two fuels but neither fuel was very toxic. The LD50/14 was 43 ml/kg for P-DFM and 50 ml/kg for S-DFM. Lesions in rats that died indicated hepatic and renal toxicity. In another study, rats were gavaged with 24 ml/kg of either P- or S-DFM and killed at 1, 2, or 3 days after dosing. Prominent clinicopathologic findings included loss of body weight, hematologic evidence of dehydration, transient leukopenia, and serum chemistry and histopathologic alterations indicative of mild hepatic and renal toxicity.
|
pubmed:language |
eng
|
pubmed:journal | |
pubmed:citationSubset |
IM
|
pubmed:chemical | |
pubmed:status |
MEDLINE
|
pubmed:month |
Jul
|
pubmed:issn |
0272-0590
|
pubmed:author | |
pubmed:issnType |
Print
|
pubmed:volume |
7
|
pubmed:owner |
NLM
|
pubmed:authorsComplete |
Y
|
pubmed:pagination |
101-5
|
pubmed:dateRevised |
2006-11-15
|
pubmed:meshHeading |
pubmed-meshheading:3732660-Animals,
pubmed-meshheading:3732660-Blood Cell Count,
pubmed-meshheading:3732660-Blood Chemical Analysis,
pubmed-meshheading:3732660-Body Weight,
pubmed-meshheading:3732660-Enzymes,
pubmed-meshheading:3732660-Fuel Oils,
pubmed-meshheading:3732660-Lethal Dose 50,
pubmed-meshheading:3732660-Liver,
pubmed-meshheading:3732660-Male,
pubmed-meshheading:3732660-Petroleum,
pubmed-meshheading:3732660-Rats,
pubmed-meshheading:3732660-Rats, Inbred Strains,
pubmed-meshheading:3732660-Time Factors
|
pubmed:year |
1986
|
pubmed:articleTitle |
Acute toxicity of petroleum- and shale-derived distillate fuel, marine: light microscopic, hematologic, and serum chemistry studies.
|
pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, Non-P.H.S.
|