Linked Life Data

3730475

Source:http://linkedlifedata.com/resource/pubmed/id/3730475

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
1986-9-16
pubmed:abstractText
The distribution of radioactivity in pregnant mice was registered at different time intervals (0-24 h) after a 10-min period of inhalation of 14C-labelled chloroform and methyl chloroform. Autoradiographic and liquid scintillation methods were used to make possible the distinction between volatile (non-metabolized), water-soluble and firmly tissue-bound radioactivity. Methyl chloroform was retained longer in fat as compared to chloroform. Metabolites of chloroform were present in a much greater abundance than those of methyl chloroform and they were found preferentially in the respiratory tract (nasal mucosa, trachea and bronchi), liver and excretory organs. Tissue-bound activity after chloroform inhalation or i.p. injection to newborn mice was found in the respiratory tract and centrilobular areas of the liver. Volatile radioactivity was observed in the placenta and fetuses at short time intervals after inhalation of both chloroform and methyl chloroform at all stages of gestation. While a low level of radioactive metabolites of methyl chloroform was observed in the fetoplacental unit, metabolites of chloroform accumulated with time. This fact was especially marked in the amniotic fluid, where the peak level of radioactivity was observed at 4 h. In early gestation, metabolites accumulated in the embryonic neural tissues. Tissue-bound metabolites of chloroform were observed in the fetal respiratory epithelium in late gestation, indicating a capacity for drug metabolism in these cells in the late fetal period.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0724-438X
pubmed:author
pubmed:issnType
Print
pubmed:volume
7
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
77-83
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1986
pubmed:articleTitle
Distribution of chloroform and methyl chloroform and their metabolites in pregnant mice.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't