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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
1986-7-28
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pubmed:abstractText |
Mannose receptor mediated uptake by the reticuloendothelial system has been suggested as an explanation for the rapid removal of ricin A chain antibody conjugates from the circulation after their administration. We have measured, in the rat, hepatic uptake of a ricin A chain antibody conjugate in vivo and its susceptibility to inhibition by a mannosylated protein and have measured uptake of the conjugate in vitro by rat parenchymal and non-parenchymal liver cells. The results indicate that rapid hepatic uptake of conjugate does occur in vivo; cultured non-parenchymal cells accumulate the conjugate to a much greater degree than cultured parenchymal cells and that mannose receptors appear to be involved in the process.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jun
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pubmed:issn |
0006-291X
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pubmed:author |
|
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pubmed:issnType |
Print
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pubmed:day |
13
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pubmed:volume |
137
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
892-6
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:3729944-Animals,
pubmed-meshheading:3729944-Antibodies,
pubmed-meshheading:3729944-Energy Metabolism,
pubmed-meshheading:3729944-Lectins, C-Type,
pubmed-meshheading:3729944-Liver,
pubmed-meshheading:3729944-Male,
pubmed-meshheading:3729944-Mannose-Binding Lectins,
pubmed-meshheading:3729944-Rats,
pubmed-meshheading:3729944-Rats, Inbred Strains,
pubmed-meshheading:3729944-Receptors, Cell Surface,
pubmed-meshheading:3729944-Receptors, Immunologic,
pubmed-meshheading:3729944-Ricin,
pubmed-meshheading:3729944-Tissue Distribution
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pubmed:year |
1986
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pubmed:articleTitle |
Mannose receptor dependent uptake of a ricin A chain--antibody conjugate by rat liver non-parenchymal cells.
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pubmed:publicationType |
Journal Article,
In Vitro
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