|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
5
|
|
pubmed:dateCreated |
1979-9-17
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|
pubmed:abstractText |
The effectiveness of pyridostigmine pretreatment against soman poisoning has been determined in rhesus monkeys and marmosets receiving atropine therapy. Pretreatment with the maximum sign-free dose (200 microgram kg-1, i.v.) raised the subcutaneous LD50 of soman by a factor of 28 in rhesus monkeys and 15 in marmosets. The protection afforded by a quarter of the sign-free dose of pyridostigmine was not significantly less. These levels of protection are higher than any reported in non-primate species.
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|
pubmed:language |
eng
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|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
May
|
|
pubmed:issn |
0022-3573
|
|
pubmed:author |
|
|
pubmed:issnType |
Print
|
|
pubmed:volume |
31
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
295-9
|
|
pubmed:dateRevised |
2006-11-15
|
|
pubmed:meshHeading |
pubmed-meshheading:37298-Animals,
pubmed-meshheading:37298-Atropine,
pubmed-meshheading:37298-Callitrichinae,
pubmed-meshheading:37298-Cholinesterases,
pubmed-meshheading:37298-Female,
pubmed-meshheading:37298-Haplorhini,
pubmed-meshheading:37298-Lethal Dose 50,
pubmed-meshheading:37298-Macaca mulatta,
pubmed-meshheading:37298-Male,
pubmed-meshheading:37298-Organophosphorus Compounds,
pubmed-meshheading:37298-Pyridostigmine Bromide,
pubmed-meshheading:37298-Soman,
pubmed-meshheading:37298-Time Factors
|
|
pubmed:year |
1979
|
|
pubmed:articleTitle |
The protection of primates against soman poisoning by pretreatment with pyridostigmine.
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|
pubmed:publicationType |
Journal Article
|
