Linked Life Data

3725913

Source:http://linkedlifedata.com/resource/pubmed/id/3725913

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
6
pubmed:dateCreated
1986-8-11
pubmed:abstractText
A number of factors have previously been demonstrated to influence the severity of stress-induced gastric ulceration in rats, including prior exposure to pre-shock and allowing animals a post-stress rest or recovery period. The primary purpose of this experiment was to investigate how one of these factors might modulate the expression of the other. Animals were pre-exposed to either signalled or unsignalled shock (using "learned helplessness" parameters), or no shock. They were later subjected to 2 hours restraint-in-water (immersion) stress, or appropriate handling control procedures. Half of the animals were sacrificed immediately on removal from the water-restraint, and half were sacrificed after a 2 hour recovery period in their home cages. Analysis of the severity and number of glandular stomach lesions indicated that animals subjected to the pre-shock exhibited greater ulceration than unshocked animals, as long as no post-stress rest period was allowed. Additionally, the effect of post-stress rest was masked by experience with pre-shock. This reciprocal modulation of treatment influences may offer suggestions for understanding discrepancies in the literature on the effects of these two modulating variables.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0031-9384
pubmed:author
pubmed:issnType
Print
pubmed:volume
36
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1093-7
pubmed:dateRevised
2008-11-21
pubmed:meshHeading
pubmed:year
1986
pubmed:articleTitle
Interactions amongst factors which influence severity of gastric ulceration in rats.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Research Support, Non-U.S. Gov't