| pubmed-article:3724768 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:3724768 | lifeskim:mentions | umls-concept:C1257890 | lld:lifeskim |
| pubmed-article:3724768 | lifeskim:mentions | umls-concept:C0086418 | lld:lifeskim |
| pubmed-article:3724768 | lifeskim:mentions | umls-concept:C0001779 | lld:lifeskim |
| pubmed-article:3724768 | lifeskim:mentions | umls-concept:C0079399 | lld:lifeskim |
| pubmed-article:3724768 | lifeskim:mentions | umls-concept:C0024264 | lld:lifeskim |
| pubmed-article:3724768 | lifeskim:mentions | umls-concept:C0441655 | lld:lifeskim |
| pubmed-article:3724768 | lifeskim:mentions | umls-concept:C0004083 | lld:lifeskim |
| pubmed-article:3724768 | lifeskim:mentions | umls-concept:C1511636 | lld:lifeskim |
| pubmed-article:3724768 | lifeskim:mentions | umls-concept:C0936012 | lld:lifeskim |
| pubmed-article:3724768 | lifeskim:mentions | umls-concept:C0205248 | lld:lifeskim |
| pubmed-article:3724768 | pubmed:issue | 2 | lld:pubmed |
| pubmed-article:3724768 | pubmed:dateCreated | 1986-8-8 | lld:pubmed |
| pubmed-article:3724768 | pubmed:abstractText | Levels of human blood granular lymphocyte subpopulations were enumerated in 105 healthy donors ranging in age from 0 to 79 years. Using double-label immunofluorescence, subpopulations of granular lymphocytes were enumerated as follows: Leu7+Leu2+, Leu7+Leu3+, Leu7+11-, Leu7+77+ and Leu7-Leu11+. The proportion of cells with granular lymphocyte morphology was determined by Giemsa staining. Natural killer (NK) cell activity against K-562 cells and lymphokine-activated killer activity against non-cultured melanoma cells were examined in parallel. Levels of total Leu7+ and Leu11+ cells increased with age (p = 0.0001) and were higher in males than females (p = 0.001). The total number of cells with granular lymphocyte morphology had an age-related increase (p = 0.001), but were not significantly higher in males than in females (p = 0.07). There was no selective increase in one granular lymphocyte subpopulation versus another since the Leu7+Leu11- (p = 0.0001), the Leu7+Leu11+ (p = 0.0001), the Leu7+Leu2+ (p = 0.0001) and the Leu7+Leu3+ (p = 0.0004) all had similar age-related increases. The one exception was the Leu7-Leu11+ (p = 0.1) granular lymphocyte subset which was low in the first decade of life but had reached maximum levels in the second decade. NK cell activity against K-562 cells was moderately increased with age (p = 0.06) with males and females exhibiting comparable activity. In contrast. lymphokine-activated killer cytotoxicity of non-cultured melanoma cells was similar in all age groups. NK cell activity was highly correlated with levels of morphologically defined granular lymphocytes (p = 0.005) and moderately with total Leu11+ cells (p = 0.06) but not with other subpopulations of granular lymphocytes. | lld:pubmed |
| pubmed-article:3724768 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3724768 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3724768 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3724768 | pubmed:language | eng | lld:pubmed |
| pubmed-article:3724768 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3724768 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:3724768 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3724768 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3724768 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3724768 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:3724768 | pubmed:issn | 0254-7600 | lld:pubmed |
| pubmed-article:3724768 | pubmed:author | pubmed-author:ItohKK | lld:pubmed |
| pubmed-article:3724768 | pubmed:author | pubmed-author:BalchC MCM | lld:pubmed |
| pubmed-article:3724768 | pubmed:author | pubmed-author:DoughertyP... | lld:pubmed |
| pubmed-article:3724768 | pubmed:author | pubmed-author:GrossiC ECE | lld:pubmed |
| pubmed-article:3724768 | pubmed:author | pubmed-author:CloudG AGA | lld:pubmed |
| pubmed-article:3724768 | pubmed:author | pubmed-author:TildenA BAB | lld:pubmed |
| pubmed-article:3724768 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:3724768 | pubmed:volume | 5 | lld:pubmed |
| pubmed-article:3724768 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:3724768 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:3724768 | pubmed:pagination | 90-9 | lld:pubmed |
| pubmed-article:3724768 | pubmed:dateRevised | 2008-11-21 | lld:pubmed |
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| pubmed-article:3724768 | pubmed:year | 1986 | lld:pubmed |
| pubmed-article:3724768 | pubmed:articleTitle | Subpopulation analysis of human granular lymphocytes: associations with age, gender and cytotoxic activity. | lld:pubmed |
| pubmed-article:3724768 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:3724768 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:3724768 | pubmed:publicationType | Research Support, U.S. Gov't, Non-P.H.S. | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:3724768 | lld:pubmed |
