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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
2
|
| pubmed:dateCreated |
1986-8-8
|
| pubmed:abstractText |
Levels of human blood granular lymphocyte subpopulations were enumerated in 105 healthy donors ranging in age from 0 to 79 years. Using double-label immunofluorescence, subpopulations of granular lymphocytes were enumerated as follows: Leu7+Leu2+, Leu7+Leu3+, Leu7+11-, Leu7+77+ and Leu7-Leu11+. The proportion of cells with granular lymphocyte morphology was determined by Giemsa staining. Natural killer (NK) cell activity against K-562 cells and lymphokine-activated killer activity against non-cultured melanoma cells were examined in parallel. Levels of total Leu7+ and Leu11+ cells increased with age (p = 0.0001) and were higher in males than females (p = 0.001). The total number of cells with granular lymphocyte morphology had an age-related increase (p = 0.001), but were not significantly higher in males than in females (p = 0.07). There was no selective increase in one granular lymphocyte subpopulation versus another since the Leu7+Leu11- (p = 0.0001), the Leu7+Leu11+ (p = 0.0001), the Leu7+Leu2+ (p = 0.0001) and the Leu7+Leu3+ (p = 0.0004) all had similar age-related increases. The one exception was the Leu7-Leu11+ (p = 0.1) granular lymphocyte subset which was low in the first decade of life but had reached maximum levels in the second decade. NK cell activity against K-562 cells was moderately increased with age (p = 0.06) with males and females exhibiting comparable activity. In contrast. lymphokine-activated killer cytotoxicity of non-cultured melanoma cells was similar in all age groups. NK cell activity was highly correlated with levels of morphologically defined granular lymphocytes (p = 0.005) and moderately with total Leu11+ cells (p = 0.06) but not with other subpopulations of granular lymphocytes.
|
| pubmed:grant | |
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:issn |
0254-7600
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
5
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
90-9
|
| pubmed:dateRevised |
2008-11-21
|
| pubmed:meshHeading |
pubmed-meshheading:3724768-Adolescent,
pubmed-meshheading:3724768-Adult,
pubmed-meshheading:3724768-Age Factors,
pubmed-meshheading:3724768-Aged,
pubmed-meshheading:3724768-Antibodies, Monoclonal,
pubmed-meshheading:3724768-Antigens, Surface,
pubmed-meshheading:3724768-Cell Line,
pubmed-meshheading:3724768-Child,
pubmed-meshheading:3724768-Child, Preschool,
pubmed-meshheading:3724768-Cytotoxicity, Immunologic,
pubmed-meshheading:3724768-Female,
pubmed-meshheading:3724768-Humans,
pubmed-meshheading:3724768-Immunity, Cellular,
pubmed-meshheading:3724768-Immunity, Innate,
pubmed-meshheading:3724768-Killer Cells, Natural,
pubmed-meshheading:3724768-Lymphocytes,
pubmed-meshheading:3724768-Lymphokines,
pubmed-meshheading:3724768-Male,
pubmed-meshheading:3724768-Melanoma,
pubmed-meshheading:3724768-Middle Aged,
pubmed-meshheading:3724768-Sex Factors
|
| pubmed:year |
1986
|
| pubmed:articleTitle |
Subpopulation analysis of human granular lymphocytes: associations with age, gender and cytotoxic activity.
|
| pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, U.S. Gov't, Non-P.H.S.
|