Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
1986-8-6
pubmed:abstractText
Muscle capillary basement membrane width is a sensitive marker for the presence of diabetic microangiopathy. Studies have indicated that genetic factors and alterations in glucose metabolism influence muscle capillary basement membrane width. To define the role of these factors we have measured muscle capillary basement membrane thickness in controls, insulin dependent diabetics, and individuals with diabetes secondary to the ingestion of Vacor, a rat poison, which results in hyperglycemia. Hemoglobin A1 concentrations were increased in both diabetic groups, but hemoglobin A1 levels and the duration of diabetes were similar in the two diabetic groups. The muscle capillary basement membrane width was increased to a similar extent in the insulin-dependent diabetics (control, 1,781 +/- 46 vs. IDD, 2,287 +/- 144 A, P less than 0.001) and in the Vacor diabetic group (2,320 +/- 149 A, P less than 0.001). In the insulin-dependent diabetic group, 63% of the patients had a muscle capillary basement membrane width greater than two standard deviations above the mean of the controls, while in the Vacor diabetic group this figure was 56%. Despite the relatively short duration of diabetes (6.2 +/- 0.3 yr), 44% of the Vacor diabetic patients had retinopathy and 28% had proteinuria. The present study provides strong evidence that even in the absence of genetic diabetes mellitus, hyperglycemia or some other abnormality related to insulin lack can cause microvascular changes.
pubmed:grant
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/3722372-1181665, http://linkedlifedata.com/resource/pubmed/commentcorrection/3722372-1269844, http://linkedlifedata.com/resource/pubmed/commentcorrection/3722372-13632894, http://linkedlifedata.com/resource/pubmed/commentcorrection/3722372-13798069, http://linkedlifedata.com/resource/pubmed/commentcorrection/3722372-153223, http://linkedlifedata.com/resource/pubmed/commentcorrection/3722372-155428, http://linkedlifedata.com/resource/pubmed/commentcorrection/3722372-203729, http://linkedlifedata.com/resource/pubmed/commentcorrection/3722372-318626, http://linkedlifedata.com/resource/pubmed/commentcorrection/3722372-3918902, http://linkedlifedata.com/resource/pubmed/commentcorrection/3722372-4039409, http://linkedlifedata.com/resource/pubmed/commentcorrection/3722372-429479, http://linkedlifedata.com/resource/pubmed/commentcorrection/3722372-4558085, http://linkedlifedata.com/resource/pubmed/commentcorrection/3722372-5080699, http://linkedlifedata.com/resource/pubmed/commentcorrection/3722372-5115590, http://linkedlifedata.com/resource/pubmed/commentcorrection/3722372-5412988, http://linkedlifedata.com/resource/pubmed/commentcorrection/3722372-5675423, http://linkedlifedata.com/resource/pubmed/commentcorrection/3722372-6041189, http://linkedlifedata.com/resource/pubmed/commentcorrection/3722372-6130243, http://linkedlifedata.com/resource/pubmed/commentcorrection/3722372-6130244, http://linkedlifedata.com/resource/pubmed/commentcorrection/3722372-6134210, http://linkedlifedata.com/resource/pubmed/commentcorrection/3722372-6139620, http://linkedlifedata.com/resource/pubmed/commentcorrection/3722372-6243167, http://linkedlifedata.com/resource/pubmed/commentcorrection/3722372-6361554, http://linkedlifedata.com/resource/pubmed/commentcorrection/3722372-6373450, http://linkedlifedata.com/resource/pubmed/commentcorrection/3722372-6472356, http://linkedlifedata.com/resource/pubmed/commentcorrection/3722372-6656850, http://linkedlifedata.com/resource/pubmed/commentcorrection/3722372-6685073, http://linkedlifedata.com/resource/pubmed/commentcorrection/3722372-6685074, http://linkedlifedata.com/resource/pubmed/commentcorrection/3722372-6777223, http://linkedlifedata.com/resource/pubmed/commentcorrection/3722372-6971768, http://linkedlifedata.com/resource/pubmed/commentcorrection/3722372-7002513, http://linkedlifedata.com/resource/pubmed/commentcorrection/3722372-761732, http://linkedlifedata.com/resource/pubmed/commentcorrection/3722372-787786, http://linkedlifedata.com/resource/pubmed/commentcorrection/3722372-823065, http://linkedlifedata.com/resource/pubmed/commentcorrection/3722372-885298
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
AIM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jul
pubmed:issn
0021-9738
pubmed:author
pubmed:issnType
Print
pubmed:volume
78
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
102-7
pubmed:dateRevised
2009-11-18
pubmed:meshHeading
pubmed:year
1986
pubmed:articleTitle
Muscle capillary basement membrane width in patients with vacor-induced diabetes mellitus.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Research Support, U.S. Gov't, Non-P.H.S.